U 46619 | Tocris Bioscience 1932/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

U 46619

catalog :

1932/1

quantity :

1 mg

price :

210 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Lee M, Verni C, Herbig B, Diamond S. Soluble fibrin causes an acquired platelet glycoprotein VI signaling defect: implications for coagulopathy. J Thromb Haemost. 2017;: pubmed publisher
Zaborska K, Edwards G, Austin C, Wareing M. The Role of O-GlcNAcylation in Perivascular Adipose Tissue Dysfunction of Offspring of High-Fat Diet-Fed Rats. J Vasc Res. 2017;54:79-91 pubmed publisher
Choi S, Lim M, Byeon S, Lee Y. Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats. Sci Rep. 2016;6:31925 pubmed publisher
Lee M, Diamond S. A human platelet calcium calculator trained by pairwise agonist scanning. PLoS Comput Biol. 2015;11:e1004118 pubmed publisher
Coleman N, Brown B, Oliván Viguera A, Singh V, Olmstead M, Valero M, et al. New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1. Mol Pharmacol. 2014;86:342-57 pubmed publisher
Pike K, Davis S, Collins S, Lucas J, Inskip H, Wilson S, et al. Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence. Sci Rep. 2014;4:4705 pubmed publisher
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
Davis A, Shi J, Pritchard H, Chadha P, Leblanc N, Vasilikostas G, et al. Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01. Br J Pharmacol. 2013;168:773-84 pubmed publisher
White B, Smith P, Dunn W. Hydrogen sulphide-mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats. Br J Pharmacol. 2013;168:785-93 pubmed publisher
Chapman L, Aggrey A, Field D, Srivastava K, Ture S, Yui K, et al. Platelets present antigen in the context of MHC class I. J Immunol. 2012;189:916-23 pubmed publisher
Lacar B, Herman P, Hartman N, Hyder F, Bordey A. S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone. PLoS ONE. 2012;7:e31960 pubmed publisher

product information

brand :

Tocris

catalog number base :

1932

SKU :

1932/1

product name :

U 46619

units size :

1 mg

description :

Potent, stable thromboxane A2 (TP) receptor agonist

target :

Prostanoid Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

350.5

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

U 46619 is a PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 u M). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TP and TP receptors.

top caption :

Potent, stable thromboxane A2 (TP) receptor agonist

extended description :

Potent, stable thromboxane A2 (TP) receptor agonist

chemical name text :

(5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid

formula :

C21H34O4

formula text :

C21H34O4

cas num :

56985-40-1

USD :

210 USD

product details :

Potent, stable thromboxane A2 (TP) receptor agonist

alt names :

9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F2a

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage