product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
U0124
catalog :
1868
quantity :
10 mg
price :
191 USD
more info or order :
citations: 9
Reference
Philips G, Ye X, Kopec A, Carew T. MAPK establishes a molecular context that defines effective training patterns for long-term memory formation. J Neurosci. 2013;33:7565-73 pubmed publisher
Melemedjian O, Khoutorsky A, Sorge R, Yan J, Asiedu M, Valdez A, et al. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain. 2013;154:1080-91 pubmed publisher
Ye X, Marina A, Carew T. Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia. Proc Natl Acad Sci U S A. 2012;109:18162-7 pubmed publisher
Melemedjian O, Asiedu M, Tillu D, Sanoja R, Yan J, Lark A, et al. Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Mol Pain. 2011;7:70 pubmed publisher
Bentley C, Hathaway N, Widdows J, Bejta F, De Pascale C, Avella M, et al. Influence of chylomicron remnants on human monocyte activation in vitro. Nutr Metab Cardiovasc Dis. 2011;21:871-8 pubmed publisher
Kolber B, Montana M, Carrasquillo Y, Xu J, Heinemann S, Muglia L, et al. Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. J Neurosci. 2010;30:8203-13 pubmed publisher
Huang Y, Yang C, Huang C, Tai M, Hsu K. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor. J Neurosci. 2010;30:6080-93 pubmed publisher
Chen Roetling J, Li Z, Chen M, Awe O, Regan R. Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway. Neuropharmacology. 2009;56:922-8 pubmed publisher
Liverman C, Brown J, Sandhir R, Klein R, McCarson K, Berman N. Oestrogen increases nociception through ERK activation in the trigeminal ganglion: evidence for a peripheral mechanism of allodynia. Cephalalgia. 2009;29:520-31 pubmed publisher
product information
brand :
Tocris
master code :
1868
SKU :
1868/10
product name :
U0124
description :
Inactive analog of U0126 (Cat. No. 1144)
target :
MEK Inhibitors
category :
Small Molecules
unit size :
10 mg
observed molecular weight :
226.31
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Inactive analog of U0126 (Cat. No. 1144). Does not inhibit MEK at concentrations up to 100 u M. Used as a negative control. . Active Analog also available.
catalog number base :
1868
product keywords :
Mitogen-Activated Protein Kinase kinases MEK MEK 1868,
extended description :
Inactive analog of U0126 (Cat. No. 1144)
chemical name text :
Bis[amino(methylthio)methylene]butanedinitrile
formula :
C 8 H 10 N 4 S 2
formula text :
C8H10N4S2
cas num :
108923-79-1
2020 USD :
185
2021 USD :
191 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK