chemical

NSC 663284

1867/10

10 mg

323 USD

1867

1867/10

NSC 663284

Potent, selective Cdc25 phosphatase inhibitor

Cdc25 Phosphatase Inhibitors

10 mg

Small Molecules

99%

Store at +4°C

321.76

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NSC 663284 is a potent, selective inhibitor of Cdc25 dual specificity phosphatases (Ki values are 29, 95 and 89 nM for human Cdc25A, Cdc25B2 and Cdc25C respectively); 20- and 450-fold selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G1 and G2/M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC50 = 0.2 - 35 u M).

Potent selective Cdc25 phosphatase inhibitors inhibits Cyclin-Dependent Protein Kinase Cdk Kinases Dual-Specificity Phosphatases NSC663284 Cdc25 Phosphatase Cyclin-dependent Kinase CDK1 Subfamily 1867,

Potent, selective Cdc25 phosphatase inhibitor

6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione

C15H16ClN3O3

C15H16ClN3O3

383907-43-5

319

323 USD

Potent, selective Cdc25 phosphatase inhibitor