product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
PRIMA-1
catalog :
1862
quantity :
10 mg (also 50 mg)
price :
112 USD
more info or order :
citations: 3
Reference
Grinter S, Liang Y, Huang S, Hyder S, Zou X. An inverse docking approach for identifying new potential anti-cancer targets. J Mol Graph Model. 2011;29:795-9 pubmed publisher
Benakanakere I, Besch Williford C, Ellersieck M, Hyder S. Regression of progestin-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Sprague-Dawley rats by p53 reactivation and induction of massive apoptosis: a pilot study. Endocr Relat Cancer. 2009;16:85-98 pubmed publisher
Cerchietti L, Polo J, Da Silva G, Farinha P, Shaknovich R, Gascoyne R, et al. Sequential transcription factor targeting for diffuse large B-cell lymphomas. Cancer Res. 2008;68:3361-9 pubmed publisher
product information
brand :
Tocris
master code :
1862
SKU :
1862/10
product name :
PRIMA-1
description :
Restores mutant p53 activity; induces apoptosis
target :
Additional p53-related Compounds
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
185.22
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.
catalog number base :
1862
product keywords :
Restores mutant p53 activity induces apoptosis Transcription Factors Bax PUMA p53 1862,
extended description :
Restores mutant p53 activity; induces apoptosis
chemical name text :
2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
formula :
C 9 H 15 NO 3
formula text :
C9H15NO3
cas num :
5608-24-2
2020 USD :
112
2021 USD :
112 USD
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK