PRIMA-1 | Tocris Bioscience 1862/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PRIMA-1

catalog :

1862/10

quantity :

10 mg (also 50 mg)

price :

141 USD

citations: 3

Reference
Grinter S, Liang Y, Huang S, Hyder S, Zou X. An inverse docking approach for identifying new potential anti-cancer targets. J Mol Graph Model. 2011;29:795-9 pubmed publisher
Benakanakere I, Besch Williford C, Ellersieck M, Hyder S. Regression of progestin-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Sprague-Dawley rats by p53 reactivation and induction of massive apoptosis: a pilot study. Endocr Relat Cancer. 2009;16:85-98 pubmed publisher
Cerchietti L, Polo J, Da Silva G, Farinha P, Shaknovich R, Gascoyne R, et al. Sequential transcription factor targeting for diffuse large B-cell lymphomas. Cancer Res. 2008;68:3361-9 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

1862

SKU :

1862/10

product name :

PRIMA-1

Description :

Restores mutant p53 activity; induces apoptosis

target :

Additional p53-related Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

185.22

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PRIMA-1 is a selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.

extended description :

Restores mutant p53 activity; induces apoptosis

chemical name text :

2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one

formula :

C 9 H 15 NO 3

formula text :

C9H15NO3

cas num :

5608-24-2

USD :

141 USD

product details :

Restores mutant p53 activity; induces apoptosis

storage :

Store at +4°C