Ro 60-0175 fumarate | Tocris Bioscience 1854/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ro 60-0175 fumarate

catalog :

1854/10

quantity :

10 mg (also 50 mg)

price :

199 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Nagata M, Yokooji T, Nakai T, Miura Y, Tomita T, Taogoshi T, et al. Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep. 2019;9:16438 pubmed publisher
Martin C, Martin V, Trigo J, Chevarin C, Maldonado R, Fink L, et al. 5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
Kasper J, Booth R, Peris J. Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens. Synapse. 2015;69:78-85 pubmed publisher
Martin C, Gassmann M, Chevarin C, Hamon M, Rudolph U, Bettler B, et al. Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress. J Neurochem. 2014;131:566-72 pubmed publisher
Craige C, Unterwald E. Serotonin (2C) receptor regulation of cocaine-induced conditioned place preference and locomotor sensitization. Behav Brain Res. 2013;238:206-10 pubmed publisher
Manvich D, Kimmel H, Howell L. Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys. J Pharmacol Exp Ther. 2012;341:424-34 pubmed publisher
Yu H, Yamaguchi A. Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis. J Neurophysiol. 2010;103:648-58 pubmed publisher
Yu H, Yamaguchi A. 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. J Neurophysiol. 2009;102:752-65 pubmed publisher
Kawahara Y, Grimberg A, Teegarden S, Mombereau C, Liu S, Bale T, et al. Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass. J Neurosci. 2008;28:12834-44 pubmed publisher
Mbaki Y, Ramage A. Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat. Br J Pharmacol. 2008;155:343-56 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1854

SKU :

1854/10

product name :

Ro 60-0175 fumarate

description :

Potent, selective 5-HT2C agonist

target :

5-HT2C Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at RT

observed molecular weight :

342.75

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ro 60-0175 fumarate is a potent, selective 5-HT2 receptor agonist; shows selectivity for the 5-HT2C subtype (pKi values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). Centrally active following oral or systemic administration in vivo .

product keywords :

Potent selective 5-HT2C agonists Serotonin Receptors Ro60-0175 5-HT2C Receptors 1854,

extended description :

Potent, selective 5-HT2C agonist

chemical name text :

( S)-6-Chloro-5-fluoro- -methyl-1H-indole-1-ethanamine fumarate

formula :

C11H12ClFN2.C4H4O4

formula text :

C11H12ClFN2.C4H4O4

cas num :

169675-09-6

USD :

197

USD 2025 :

199 USD

product details :

Potent, selective 5-HT2C agonist

more info or order :

Tocris Bioscience product webpage