Ac2-26 | Tocris Bioscience 1845/500U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ac2-26

catalog :

1845/500U

quantity :

500 ug

price :

292 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Pessolano E, Belvedere R, Bizzarro V, Franco P, Marco I, Petrella F, et al. Annexin A1 Contained in Extracellular Vesicles Promotes the Activation of Keratinocytes by Mesoglycan Effects: An Autocrine Loop Through FPRs. Cells. 2019;8: pubmed publisher
Fredman G, Kamaly N, Spolitu S, Milton J, Ghorpade D, Chiasson R, et al. Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. Sci Transl Med. 2015;7:275ra20 pubmed publisher
Leoni G, Neumann P, Kamaly N, Quirós M, Nishio H, Jones H, et al. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest. 2015;125:1215-27 pubmed publisher
Leoni G, Gripentrog J, Lord C, Riesselman M, Sumagin R, Parkos C, et al. Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response. J Leukoc Biol. 2015;97:87-101 pubmed publisher
Dalli J, Montero Melendez T, McArthur S, Perretti M. Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils. Front Pharmacol. 2012;3:28 pubmed publisher
Brancaleone V, Dalli J, Bena S, Flower R, Cirino G, Perretti M. Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. J Immunol. 2011;186:4905-14 pubmed publisher

product information

brand :

Tocris

master code :

1845

SKU :

1845/500U

product name :

Ac2-26

description :

Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation

target :

Cell Adhesion Inhibitors

category :

Peptides

unit sizes :

500 ug

purity :

95%

observed molecular weight :

3089.46

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Ac2-26 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Ac2-26 reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo . Anti-inflammatory. Ac2-26 inhibits the proliferation of human larynx epidermoid carcinoma Hep-2 cells in vitro . Ac2-26 decreases proliferation and increases mobility of cervical cancer cells.

extended description :

Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation

formula :

C 141 H 210 N 32 O 44 S

formula text :

C141H210N32O44S

cas num :

151988-33-9

USD :

292 USD

product details :

Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage