Fostriecin sodium salt | Tocris Bioscience 1840/50U product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Fostriecin sodium salt

catalog :

1840/50U

quantity :

50 ug

price :

363 USD

citations: 7

Reference
Chiu A, Wang J, Fiske M, Hubálková P, Barse L, Gray J, et al. NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep. 2019;28:332-341.e5 pubmed publisher
Liu J, Sharma K, Zangrandi L, Chen C, Humphrey S, Chiu Y, et al. In vivo brain GPCR signaling elucidated by phosphoproteomics. Science. 2018;360: pubmed publisher
Chen Z, Xiong C, Pancyr C, Stockwell J, Walz W, Cayabyab F. Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential re. J Neurosci. 2014;34:9621-43 pubmed publisher
Pribiag H, Stellwagen D. TNF-? downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors. J Neurosci. 2013;33:15879-93 pubmed publisher
Xu T, Ma Q, Spealman R, Yao W. Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant. J Neurochem. 2010;115:1643-54 pubmed publisher
Goffin D, Ali A, Rampersaud N, Harkavyi A, Fuchs C, Whitton P, et al. Dopamine-dependent tuning of striatal inhibitory synaptogenesis. J Neurosci. 2010;30:2935-50 pubmed publisher
Xu T, Sotnikova T, Liang C, Zhang J, Jung J, Spealman R, et al. Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate. J Neurosci. 2009;29:14086-99 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

1840

SKU :

1840/50U

product name :

Fostriecin sodium salt

Description :

Potent PP2A and PP4 inhibitor

target :

Protein Ser/Thr Phosphatase Inhibitors

category :

Small Molecules

unit size :

50 ug

purity :

98%

observed molecular weight :

452.37

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Fostriecin sodium salt is a potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 u M) and protein phosphatase type 1 (PP1) (IC50 = 131 u M) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo . Originally identified as an antitumor antibiotic from Streptomyces pulveraceous .

extended description :

Potent PP2A and PP4 inhibitor

chemical name text :

(6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt

formula :

C 19 H 26 O 9 PNa

formula text :

C19H26O9PNa

cas num :

87860-39-7

USD :

363 USD

product details :

Potent PP2A and PP4 inhibitor

storage :

Desiccate at -20°C