Demethylasterriquinone B1 | Tocris Bioscience 1819/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Demethylasterriquinone B1

catalog :

1819/5

quantity :

5 mg

price :

324 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Pitt J, Wilcox K, Tortelli V, Diniz L, Oliveira M, Dobbins C, et al. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound A? oligomers. Mol Biol Cell. 2017;28:2623-2636 pubmed publisher

product information

brand :

Tocris

catalog number base :

1819

SKU :

1819/5

product name :

Demethylasterriquinone B1

units size :

5 mg

description :

Selective insulin RTK activator

target :

Insulin and Insulin-like Receptor Activators

category :

Small Molecules

purity :

95%

observed molecular weight :

506.59

url print :

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review stars :

details of functionality :

Demethylasterriquinone B1 is a selective insulin receptor (IR) activator (EC50 values are 3 - 6 u M for IRTK and 100 u M for IGF1R and EGFR). Increases IR subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro , without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.

top caption :

Selective insulin RTK activator

extended description :

Selective insulin RTK activator

chemical name text :

2-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione

formula :

C32H30N2O4

formula text :

C32H30N2O4

cas num :

78860-34-1

USD :

324 USD

product details :

Selective insulin RTK activator

alt names :

DAQ B1,L-783,281,DMAQ-B1

storage :

Desiccate at -20Â°C

more info or order :

Tocris Bioscience product webpage