product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Raclopride
catalog :
1810/10
quantity :
10 mg (also 50 mg)
price :
126 USD
more info or order :
citations: 12
Reference
Verharen J, Adan R, Vanderschuren L. Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making. Neuropsychopharmacology. 2019;44:2195-2204 pubmed publisher
Lassus B, Naudé J, Faure P, Guedin D, von Boxberg Y, Mannoury La Cour C, et al. Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips. Sci Rep. 2018;8:17461 pubmed publisher
Guo F, Zhao J, Zhao D, Wang J, Wang X, Feng Z, et al. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Aging Cell. 2017;16:1323-1333 pubmed publisher
Scardochio T, Trujillo Pisanty I, Conover K, Shizgal P, Clarke P. The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations. Front Behav Neurosci. 2015;9:331 pubmed publisher
Heath C, Bussey T, Saksida L. Motivational assessment of mice using the touchscreen operant testing system: effects of dopaminergic drugs. Psychopharmacology (Berl). 2015;232:4043-57 pubmed publisher
Jiang B, Wang F, Yang S, Fang P, Deng Z, Xiao J, et al. SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
Zheng H, Liu X, Li Y, Mishra P, Patel K. Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes. Am J Physiol Regul Integr Comp Physiol. 2014;306:R138-48 pubmed publisher
Chiodi V, Mallozzi C, Ferrante A, CHEN J, Lombroso P, Di Stasi A, et al. Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP. Neuropsychopharmacology. 2014;39:569-78 pubmed publisher
Ahmadiantehrani S, Ron D. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via G??-Erk1/2-dependent induction of Zif268. J Neurochem. 2013;125:193-204 pubmed publisher
Ogata G, Stradleigh T, Partida G, Ishida A. Dopamine and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells. J Comp Neurol. 2012;520:4032-49 pubmed publisher
Huang C, Liang Y, Lee C, Wu M, Hsu K. Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. Neuropsychopharmacology. 2009;34:1979-92 pubmed publisher
Liu T, Dartevelle L, Yuan C, Wei H, Wang Y, Ferveur J, et al. Increased dopamine level enhances male-male courtship in Drosophila. J Neurosci. 2008;28:5539-46 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
1810
SKU :
1810/10
product name :
Raclopride
description :
Potent and selective D2 and D3 antagonist
target :
Non-selective Dopamine Receptor Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Store at -20°C
observed molecular weight :
347.24
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Raclopride is a selective and potent dopamine D2/D3 receptor antagonist (Ki values are 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively). Centrally active following systemic administration in vivo .
product keywords :
Potent selective D2/D3 antagonists Dopamine D2-like Non-Selective Receptors dopaminergic Non-selective Dopamine 1810,
extended description :
Potent and selective D2 and D3 antagonist
chemical name text :
3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide
formula :
C15H20Cl2N2O3
formula text :
C15H20Cl2N2O3
cas num :
84225-95-6
USD :
122
USD 2025 :
126 USD
product details :
Potent and selective D2 and D3 antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK