E-4031 dihydrochloride | Tocris Bioscience 1808/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

E-4031 dihydrochloride

catalog :

1808/10

quantity :

10 mg (also 50 mg)

price :

264 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Song L, Bekdash R, Morikawa K, Quejada J, Klein A, Aina Badejo D, et al. Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nat Cardiovasc Res. 2022;1:142-156 pubmed publisher
Kamiya K, Osaki T, Nakao K, Kawano R, Fujii S, Misawa N, et al. Electrophysiological measurement of ion channels on plasma/organelle membranes using an on-chip lipid bilayer system. Sci Rep. 2018;8:17498 pubmed publisher
Veldkamp M, Geuzebroek G, Baartscheer A, Verkerk A, Schumacher C, Suarez G, et al. Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel. Nat Commun. 2018;9:4357 pubmed publisher
McKeithan W, Savchenko A, YU M, Cerignoli F, Bruyneel A, Price J, et al. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 2017;8:766 pubmed publisher
Zhang X, Cao H, Bai S, Huo W, Ma Y. Differentiation and characterization of rhesus monkey atrial and ventricular cardiomyocytes from induced pluripotent stem cells. Stem Cell Res. 2017;20:21-29 pubmed publisher
Pei F, Jiang J, Bai S, Cao H, Tian L, Zhao Y, et al. Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells. Stem Cell Res. 2017;19:94-103 pubmed publisher
BraganÃ§a B, Oliveira Monteiro N, Ferreirinha F, Lima P, Faria M, Fontes Sousa A, et al. Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria. Front Pharmacol. 2016;7:45 pubmed publisher
Zhang J, Cheng K, Lai D, Kong L, Shen M, Yi F, et al. Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel. Int J Clin Exp Pathol. 2015;8:10239-49 pubmed
Guo L, Eldridge S, Furniss M, Mussio J, DAVIS M. Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) to Monitor Compound Effects on Cardiac Myocyte Signaling Pathways. Curr Protoc Chem Biol. 2015;7:141-185 pubmed publisher
Yu C, Ai T, Weiss J, Chen P. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. PLoS ONE. 2014;9:e96691 pubmed publisher
Fiore A, Carraresi L, Morabito A, Polvani S, Fortunato A, Lastraioli E, et al. Characterization of hERG1 channel role in mouse colorectal carcinogenesis. Cancer Med. 2013;2:583-94 pubmed publisher

image

image 1 :

Cat.No. 1808 - E-4031 dihydrochloride C21H27N3O3S.2HCl CAS No. 113559-13-0

product information

brand :

Tocris

MasterCode :

1808

SKU :

1808/10

product name :

E-4031 dihydrochloride

target :

Voltage-gated Potassium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

474.44

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

E-4031 dihydrochloride is a selective blocker of KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents. Class III antiarrhythmic agent.

extended description :

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

chemical name text :

N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride

formula :

C 21 H 27 N 3 O 3 S.2HCl

formula text :

C21H27N3O3S.2HCl

cas num :

113559-13-0

USD :

264 USD

product details :

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage