2-Methoxyestradiol | Tocris Bioscience 1807/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

2-Methoxyestradiol

catalog :

1807/10

quantity :

10 mg (also 50 mg)

price :

90 USD

citations: 1

Reference
Valencia Cervantes J, Huerta Yepez S, Aquino Jarquin G, Rodriguez Enriquez S, Martinez Fong D, Arias Montaño J, et al. Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia‑inducible factor 1α‑mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation. Oncol Rep. 2019;41:178-190 pubmed publisher

product information

brand :

Tocris

master code :

1807

SKU :

1807/10

product name :

2-Methoxyestradiol

target :

Apoptosis Inducer Compounds

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

302.41

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

extended description :

Apoptotic and antiangiogenic agent

chemical name text :

(17 )-2-Methoxyestra-1,3,5(10)-triene-3,17-diol

formula :

C 19 H 26 O 3

formula text :

C19H26O3

cas num :

362-07-2

USD :

90 USD

product details :

Apoptotic and antiangiogenic agent

storage :

Store at RT