ITE | Tocris Bioscience 1803/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ITE

catalog :

1803/10

quantity :

10 mg

price :

299 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Iyer S, Gensollen T, Gandhi A, Oh S, Neves J, Collin F, et al. Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses. Cell. 2018;173:1123-1134.e11 pubmed publisher
Boule L, Burke C, Jin G, Lawrence B. Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome. Sci Rep. 2018;8:1826 pubmed publisher
Baker S, Arlt V, Indra R, Joel M, Stiborova M, Eardley I, et al. Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of "luminal" muscle-invasive bladder cancers. Mol Carcinog. 2018;57:606-618 pubmed publisher
Fusco D, Pratt H, Kandilas S, Cheon S, Lin W, Cronkite D, et al. HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus. Front Microbiol. 2017;8:240 pubmed publisher
Wang C, Ye Z, Kijlstra A, Zhou Y, Yang P. Decreased expression of the aryl hydrocarbon receptor in ocular Behcet's disease. Mediators Inflamm. 2014;2014:195094 pubmed publisher
Wu Y, Chen X, Zhou Q, He Q, Kang J, Zheng J, et al. ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR. PLoS ONE. 2014;9:e86549 pubmed publisher
Nugent L, Shi G, Vistica B, Ogbeifun O, Hinshaw S, Gery I. ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity. Invest Ophthalmol Vis Sci. 2013;54:7463-9 pubmed publisher
Wang K, Li Y, Jiang Y, Dai C, Patankar M, Song J, et al. An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells. Cancer Lett. 2013;340:63-71 pubmed publisher
Yeste A, Nadeau M, Burns E, Weiner H, Quintana F. Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2012;109:11270-5 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1803

SKU :

1803/10

product name :

ITE

description :

Endogenous agonist for the transcription factor aryl hydrocarbon receptor

target :

Aryl Hydrocarbon Receptor Agonists

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

286.3

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro . Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF- -induced human myofibroblast differentiation.

product keywords :

Endogenous agonists transcription factor aryl hydrocarbon receptor AHR Receptors myofibroblast differentiation inhibits inhibitors stem cells stem-like cancer Aryl hydrocarbon receptor ligand Aryl Hydrocarbon Receptors Cancer Stem Cells Cancer Stem Cell Differentiation 1803,

extended description :

Endogenous agonist for the transcription factor aryl hydrocarbon receptor

chemical name text :

2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester

formula :

C14H10N2O3S

formula text :

C14H10N2O3S

cas num :

448906-42-1

USD :

290

USD 2025 :

299 USD

product details :

Endogenous agonist for the transcription factor aryl hydrocarbon receptor

alt names :

Aryl hydrocarbon receptor ligand

more info or order :

Tocris Bioscience product webpage