NNC 711 | Tocris Bioscience 1779/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NNC 711

catalog :

1779/10

quantity :

10 mg (also 50 mg)

price :

267 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
KersantÃ© F, Rowley S, Pavlov I, GutiÃ¨rrez Mecinas M, Semyanov A, Reul J, et al. A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus. J Physiol. 2013;591:2429-41 pubmed publisher
Yoshizumi M, Parker R, Eisenach J, Hayashida K. Gabapentin inhibits ?-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. Anesthesiology. 2012;116:1347-53 pubmed publisher
Samoudi G, Nissbrandt H, Dutia M, Bergquist F. Noisy galvanic vestibular stimulation promotes GABA release in the substantia nigra and improves locomotion in hemiparkinsonian rats. PLoS ONE. 2012;7:e29308 pubmed publisher
Héja L, Barabas P, Nyitrai G, Kekesi K, Lasztóczi B, Toke O, et al. Glutamate uptake triggers transporter-mediated GABA release from astrocytes. PLoS ONE. 2009;4:e7153 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1779

SKU :

1779/10

product name :

NNC 711

description :

Selective GAT-1 inhibitor

target :

GABA Transporter Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Desiccate at +4°C

observed molecular weight :

386.88

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NNC 711 is a potent and selective inhibitor of GABA uptake by GAT-1 (IC50 values are 0.04, 171, 1700 and 622 M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Anticonvulsant following systemic administration in vivo . Also exhibits cognition-enhancing activity.

product keywords :

Selective inhibitors inhibits GAT-1 GABA Transporters Monoamine Neurotransmitter NNC711 GABA Transporters 1779,

extended description :

Selective GAT-1 inhibitor

chemical name text :

1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride

formula :

C21H22N2O3.HCl

formula text :

C21H22N2O3.HCl

cas num :

145645-62-1

USD :

264

USD 2025 :

267 USD

product details :

Selective GAT-1 inhibitor

more info or order :

Tocris Bioscience product webpage