Arctigenin | Tocris Bioscience 1777 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Arctigenin

catalog :

1777

quantity :

10 mg (also 50 mg)

price :

93 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Rycaj K, Cho E, Liu X, Chao H, Liu B, Li Q, et al. Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA-/lo castration-resistant cells. Oncotarget. 2016;7:14220-40 pubmed publisher
Ogungbe I, Crouch R, Demeritte T. (-) Arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor Î². J Chem Inf Model. 2014;54:3051-5 pubmed publisher

product information

brand :

Tocris

master code :

1777

SKU :

1777/10

product name :

Arctigenin

description :

Potent MEK1 inhibitor. Also inhibits I B phosphorylation

target :

MEK Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

372.42

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of I B phosphorylation and p65 nuclear translocation (IC50 = 10 nM). Inhibits HIV-1 replication in vitro . Also potently inhibits MKK1 (MEK1) (IC50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors.

catalog number base :

1777

product keywords :

inhibitors I B I B IkappaBalpha phosphorylation inhibits MKK1 kainate receptors Nuclear Factor Kappa B Glutamate Kainate Receptors iGluR Ionotropic Transcription Factors antiviral NF-kB NF-kappaB NF- B (-)-Arctigenin NF-kB/IkB MEK Kainate Receptors HIV 1777,

extended description :

Potent MEK1 inhibitor. Also inhibits I B phosphorylation

chemical name text :

(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone

formula :

C 21 H 24 O 6

formula text :

C21H24O6

cas num :

7770-78-7

2020 USD :

2021 USD :

93 USD

alt names :

(-)-Arctigenin

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage