Arctigenin | Tocris Bioscience 1777/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Arctigenin

catalog :

1777/10

quantity :

10 mg (also 50 mg)

price :

116 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Rycaj K, Cho E, Liu X, Chao H, Liu B, Li Q, et al. Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA-/lo castration-resistant cells. Oncotarget. 2016;7:14220-40 pubmed publisher
Ogungbe I, Crouch R, Demeritte T. (-) Arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor Î². J Chem Inf Model. 2014;54:3051-5 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1777

SKU :

1777/10

product name :

Arctigenin

description :

Potent MEK1 inhibitor. Also inhibits I B phosphorylation

target :

MEK Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

372.42

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Arctigenin is an antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of I B phosphorylation and p65 nuclear translocation (IC50 = 10 nM). Inhibits HIV-1 replication in vitro . Also potently inhibits MKK1 (MEK1) (IC50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors.

product keywords :

inhibitors I B I B IkappaBalpha phosphorylation inhibits MKK1 kainate receptors Nuclear Factor Kappa B Glutamate Kainate Receptors iGluR Ionotropic Transcription Factors antiviral NF-kB NF-kappaB NF- B (-)-Arctigenin NF-kB/IkB MEK Kainate Receptors HIV 1777,

extended description :

Potent MEK1 inhibitor. Also inhibits I B phosphorylation

chemical name text :

(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone

formula :

C21H24O6

formula text :

C21H24O6

cas num :

7770-78-7

USD :

114

USD 2025 :

116 USD

product details :

Potent MEK1 inhibitor. Also inhibits I B phosphorylation

alt names :

(-)-Arctigenin

more info or order :

Tocris Bioscience product webpage