BAM (8-22) | Tocris Bioscience 1763/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BAM (8-22)

catalog :

1763/1

quantity :

1 mg

price :

489 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Grundy L, Caldwell A, Garcia Caraballo S, Grundy D, Spencer N, Dong X, et al. Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension. J Neurosci. 2021;41:3900-3916 pubmed publisher
Honda M, Tsounapi P, Teraoka S, Kimura Y, Hikita K, Takenaka A. Effects of intravesical administration of sensory neuron-specific receptor agonist on voiding function in rats with cyclophosphamide-induced cystitis. Cent European J Urol. 2019;72:142-148 pubmed publisher
Sanjel B, Maeng H, Shim W. BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus. Sci Rep. 2019;9:10888 pubmed publisher
Hin N, Alt J, Zimmermann S, Delahanty G, Ferraris D, Rojas C, et al. Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. Bioorg Med Chem. 2014;22:5831-7 pubmed publisher
Moser H, Giesler G. Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. J Neurosci. 2013;33:6093-101 pubmed publisher

product information

brand :

Tocris

catalog number base :

1763

SKU :

1763/1

product name :

BAM (8-22)

units size :

1 mg

description :

Potent MRGPRX1 agonist

target :

Mas-Related G Protein Coupled Receptor Agonists

category :

Peptides

purity :

95%

observed molecular weight :

1971.22

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides

review stars :

details of functionality :

BAM (8-22) is an endogenous peptide fragment that is a potent agonist for MRGPRX1 (EC50 values are 8 - 150 nM). It was first isolated from bovine adrenal medulla. Unlike BAM 22P (Cat. No. 1650), BAM (8-22) does not contain the met-enkephalin motif therefore displays no affinity for opioid receptors. BAM (8-22) augments scratching behavior in a cholestatic pruritus mice model. BAM (8-22) attenuates bone cancer pain in mice.

top caption :

Potent MRGPRX1 agonist

extended description :

Potent MRGPRX1 agonist

formula :

C91H127N25O23S

formula text :

C91H127N25O23S

cas num :

412961-36-5

USD :

489 USD

product details :

Potent MRGPRX1 agonist

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage