Baicalein | Tocris Bioscience 1761/50 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Baicalein

catalog :

1761/50

quantity :

50 mg

price :

122 USD

citations: 6

Reference
Oguh Olayinka L, Agarwal V, Ranatunge D, Campbell A, Laufer S, Cawkwell L, et al. The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma. Pathol Oncol Res. 2019;: pubmed publisher
Mishra B, Lovewell R, Olive A, Zhang G, Wang W, Eugenin E, et al. Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nat Microbiol. 2017;2:17072 pubmed publisher
Maskrey B, Rushworth G, Law M, Treweeke A, Wei J, Leslie S, et al. 12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition. J Inflamm (Lond). 2014;11:33 pubmed publisher
Potapova I, Cohen I, Doronin S. Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. PLoS ONE. 2013;8:e73929 pubmed publisher
Starowicz K, Makuch W, Korostynski M, Malek N, Slezak M, Zychowska M, et al. Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. PLoS ONE. 2013;8:e60040 pubmed publisher
Gibson H, Edwards J, Page R, Van Hook M, Kauer J. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron. 2008;57:746-59 pubmed publisher

product information

brand :

Tocris

master code :

1761

SKU :

1761/50

product name :

Baicalein

description :

5- and 12-Lipoxygenase inhibitor

target :

Lipoxygenase Inhibitors

category :

Small Molecules

unit sizes :

50 mg

purity :

98%

observed molecular weight :

270.24

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Baicalein is an inhibitor of 5- and platelet 12-lipoxygenases (IC50 values are 9.5 and 0.12 M respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF- B activation. Also inhibits erastin-induced ferroptosis.

extended description :

5- and 12-Lipoxygenase inhibitor

chemical name text :

5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one

formula :

C 15 H 10 O 5

formula text :

C15H10O5

cas num :

491-67-8

USD :

122 USD

product details :

5- and 12-Lipoxygenase inhibitor

storage :

Desiccate at -20°C