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company name :
Tocris Bioscience
product type :
chemical
product name :
MG 132
catalog :
1748/5
quantity :
5 mg
price :
173 USD
more info or order :
citations: 70
Reference
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product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
1748
SKU :
1748/5
product name :
MG 132
description :
Proteasome and calpain inhibitor. Inhibits NF- B activation
target :
Calpain Inhibitors
unit size :
5 mg
category :
Small Molecules
purity :
95%
storage :
Store at -20°C
observed molecular weight :
475.63
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
MG 132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 M). MG 132 inhibits TNF- -induced NF- B activation and I B degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro . MG 132 inhibits SARS-CoV-2 Mpro in vitro (IC50 = 3.9 M) and inhibits viral replication. Also enhances adeno-associated viral transduction efficiency of human cell lines by around 50-fold.
product keywords :
Proteasome calpain inhibitors inhibits NF- B NF-kappaB NF-kB activation Transcription Factors Nuclear Factor Kappa B Proteinases Proteases Ca2+Sensitive Protease modulators Calcium-Sensitive MG132 anticancer viral transduction enhancers enhances SARS Z-LLL-al Z-Leu-Leu-Leu-CHO Calpains NF-kB/IkB Calcium-Sensitive Proteases Proteasome 3C and 3CL Proteases Viral Transduction Enhancers 1748,
extended description :
Proteasome and calpain inhibitor. Inhibits NF- B activation
chemical name text :
N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
formula :
C26H41N3O5
formula text :
C26H41N3O5
cas num :
133407-82-6
USD :
166
USD 2025 :
173 USD
product details :
Proteasome and calpain inhibitor. Inhibits NF- B activation
alt names :
Z-LLL-al,Z-Leu-Leu-Leu-CHO
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK