5-Iodotubercidin | Tocris Bioscience 1745 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5-Iodotubercidin

catalog :

1745

quantity :

1 mg

price :

151 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
RÃ¼ben K, Wurzlbauer A, Walte A, Sippl W, Bracher F, Becker W. Selectivity Profiling and Biological Activity of Novel Î²-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors. PLoS ONE. 2015;10:e0132453 pubmed publisher
Baron L, Gombault A, Fanny M, Villeret B, Savigny F, Guillou N, et al. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine. Cell Death Dis. 2015;6:e1629 pubmed publisher
Visentin M, Zhao R, Goldman I. Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate. Mol Pharmacol. 2012;82:209-16 pubmed publisher
Prakasam H, Herrington H, Roppolo J, Jackson E, Apodaca G. Modulation of bladder function by luminal adenosine turnover and A1 receptor activation. Am J Physiol Renal Physiol. 2012;303:F279-92 pubmed publisher
Bumpus N, Johnson E. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated pro. J Pharmacol Exp Ther. 2011;339:886-95 pubmed publisher
Fassett J, Hu X, Xu X, Lu Z, Zhang P, Chen Y, et al. Adenosine kinase regulation of cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol. 2011;300:H1722-32 pubmed publisher

product information

brand :

Tocris

master code :

1745

SKU :

1745/1

product name :

5-Iodotubercidin

description :

Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases

target :

Adenosine Kinase Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

90%

observed molecular weight :

392.15

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent adenosine kinase inhibitor (IC50 = 26 nM). Also nucleoside transporter inhibitor (IC50 values are 25 nM, 7 M and 15 M for inhibition of [3H]adenosine, [3H]uridine and [3H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 M respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo .

catalog number base :

1745

product keywords :

Potent adenosines kinase inhibitors nucleoside transporters ENT1 reuptake Purine Transporters Pyrimidine Equilibrative Monoamine Neurotransmitter ADK 5-it inhibits DNA methylation Adenosine Kinase Broad Spectrum Protein Kinase Inhibitors Nucleoside Transporters Other Adenosine DNA Methyltransferases 1745,

extended description :

Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases

chemical name text :

5-Iodo-7- -D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

formula :

C 11 H 13 IN 4 O 4

formula text :

C11H13IN4O4

cas num :

24386-93-4

2020 USD :

145

2021 USD :

151 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage