Bay 11-7821 | Tocris Bioscience 1744/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Bay 11-7821

catalog :

1744/10

quantity :

10 mg

price :

196 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Ahn H, Han B, Kim J, Kang S, Kim P, Jang K, et al. Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression. J Ginseng Res. 2019;43:291-299 pubmed publisher
Zhou X, An D, Liu X, Jiang M, Yuan C, Hu J. TNF? induces tolerant production of CXC chemokines in colorectal cancer HCT116 cells via A20 inhibition of ERK signaling. Int Immunopharmacol. 2018;54:296-302 pubmed publisher
Jiang W, Li M, He F, Zhou S, Zhu L. Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice. J Neuroinflammation. 2017;14:207 pubmed publisher
Han B, Ahn H, Lee J, Jeon E, Seo S, Jang K, et al. Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome. J Ginseng Res. 2017;41:513-523 pubmed publisher
Yu Y, Yip K, Tam I, Sam S, Ng C, Zhang W, et al. Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation. PLoS ONE. 2014;9:e112989 pubmed publisher
Jia D, Yang W, Li L, Liu H, Tan Y, Ooi S, et al. Î²-Catenin and NF-ÎºB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death Differ. 2015;22:298-310 pubmed publisher
Clement M, Fornasa G, Guedj K, Ben Mkaddem S, Gaston A, Khallou Laschet J, et al. CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells. Proc Natl Acad Sci U S A. 2014;111:E1101-10 pubmed publisher
Yang Y, Groshong J, Matta H, Gopalakrishnan R, Yi H, Chaudhary P. Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells. J Biol Chem. 2011;286:27988-97 pubmed publisher

image

image 1 :

Cat.No. 1744 - Bay 11-7821 C10H9NO2S CAS No. 19542-67-7

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1744

SKU :

1744/10

product name :

Bay 11-7821

description :

E2 ubiquitin (Ub) conjugating enzymes inhibitor

target :

Ubiquitin Conjugating Enzyme (E2) Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

207.25

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Bay 11-7821 is an E2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated I B phosphorylation and indirectly decreases NF- b activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. Also inhibits activation of NLRP3 inflammasome. Binds and inhibits gasdermin D (GSDMD) pore formation. Pyroptosis inhibitor.

product keywords :

Irreversible inhibitors inhibits TNF- TNF-alpha-induced I B I B IkappaBalpha phosphorylation IkappaB Nuclear Factor Kappa B NF- B NF-kappaB and Cytokine Signaling Signalling Transcription Factors Bay11-7821 Bay117082 NF-kB NLRP3 Bay 11-7082 NF-kB/IkB Post-translational Modifications Ubiquitin/Ubl E2 Conjugating Enzymes Inflammasomes 1744,

extended description :

E2 ubiquitin (Ub) conjugating enzymes inhibitor

chemical name text :

(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile

formula :

C10H9NO2S

formula text :

C10H9NO2S

cas num :

19542-67-7

USD :

194

USD 2025 :

196 USD

product details :

E2 ubiquitin (Ub) conjugating enzymes inhibitor

alt names :

Bay 11-7082

more info or order :

Tocris Bioscience product webpage