Bay 11-7085 | Tocris Bioscience 1743 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Bay 11-7085

catalog :

1743

quantity :

10 mg

price :

161 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Liang Y, Xing X, Beamer M, Swindell W, Sarkar M, Roberts L, et al. Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders. J Allergy Clin Immunol. 2017;139:1217-1227 pubmed publisher
Kwon O, Zhang L, Wang J, Su Q, Feng Q, Zhang X, et al. Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. J Clin Invest. 2016;126:2626-41 pubmed publisher
Clark P, Kim R, Pober J, Kluger M. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-ÎºB-dependent phases. PLoS ONE. 2015;10:e0120075 pubmed publisher
Kwon O, Valdez J, Zhang L, Zhang B, Wei X, Su Q, et al. Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells. Nat Commun. 2014;5:4416 pubmed publisher
Przybyla L, Theunissen T, Jaenisch R, Voldman J. Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells. 2013;31:1097-106 pubmed publisher
Hussain A, Ahmed S, Ahmed M, Khan O, Al Abdulmohsen S, Platanias L, et al. Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis. PLoS ONE. 2012;7:e39945 pubmed publisher

product information

brand :

Tocris

master code :

1743

SKU :

1743/10

product name :

Bay 11-7085

description :

Irreversible inhibitor of TNF- -induced I B phosphorylation

target :

NFkB/IkB Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

99%

observed molecular weight :

249.33

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Irreversible inhibitor of TNF- -stimulated I B phosphorylation (IC50 ~ 10 u M); leads to decreased NF- B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo .

catalog number base :

1743

product keywords :

Irreversible inhibitors inhibits TNF- TNF-alpha-induced I B I B IkappaBalpha phosphorylation IkappaB Nuclear Factor Kappa B NF- B NF-kappaB NF-kB Cytokine Signaling Signalling Transcription Factors Bay11-7085 Bay117083 Bay 11-7083 NF-kB/IkB 1743,

extended description :

Irreversible inhibitor of TNF- -induced I B phosphorylation

chemical name text :

(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile

formula :

C 13 H 15 NO 2 S

formula text :

C13H15NO2S

cas num :

196309-76-9

2020 USD :

154

2021 USD :

161 USD

alt names :

Bay 11-7083

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage