Bay 11-7085 | Tocris Bioscience 1743/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Bay 11-7085

catalog :

1743/10

quantity :

10 mg

price :

204 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Li N, Hui H, Bray B, Gonzalez G, Zeller M, Anderson K, et al. METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection. Cell Rep. 2021;35:109091 pubmed publisher
Liang Y, Xing X, Beamer M, Swindell W, Sarkar M, Roberts L, et al. Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders. J Allergy Clin Immunol. 2017;139:1217-1227 pubmed publisher
Pinte S, Caetano B, Le Bras A, Havet C, Villain G, Dernayka R, et al. Endothelial Cell Activation Is Regulated by Epidermal Growth Factor-like Domain 7 (Egfl7) during Inflammation. J Biol Chem. 2016;291:24017-24028 pubmed
Kwon O, Zhang L, Wang J, Su Q, Feng Q, Zhang X, et al. Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. J Clin Invest. 2016;126:2626-41 pubmed publisher
Clark P, Kim R, Pober J, Kluger M. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-ÎºB-dependent phases. PLoS ONE. 2015;10:e0120075 pubmed publisher
Kwon O, Valdez J, Zhang L, Zhang B, Wei X, Su Q, et al. Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells. Nat Commun. 2014;5:4416 pubmed publisher
Przybyla L, Theunissen T, Jaenisch R, Voldman J. Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells. 2013;31:1097-106 pubmed publisher
Balzarolo M, Karrich J, Engels S, Blom B, Medema J, Wolkers M. The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs. Eur J Immunol. 2012;42:3019-27 pubmed publisher
Hussain A, Ahmed S, Ahmed M, Khan O, Al Abdulmohsen S, Platanias L, et al. Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis. PLoS ONE. 2012;7:e39945 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1743

SKU :

1743/10

product name :

Bay 11-7085

description :

Irreversible inhibitor of TNF- -induced I B phosphorylation

target :

NFkB/IkB Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

249.33

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Bay 11-7085 is an irreversible inhibitor of TNF- -stimulated I B phosphorylation (IC50 ~ 10 u M); leads to decreased NF- B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo .

product keywords :

Irreversible inhibitors inhibits TNF- TNF-alpha-induced I B I B IkappaBalpha phosphorylation IkappaB Nuclear Factor Kappa B NF- B NF-kappaB NF-kB Cytokine Signaling Signalling Transcription Factors Bay11-7085 Bay117083 Bay 11-7083 NF-kB/IkB 1743,

extended description :

Irreversible inhibitor of TNF- -induced I B phosphorylation

chemical name text :

(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile

formula :

C13H15NO2S

formula text :

C13H15NO2S

cas num :

196309-76-9

USD :

201

USD 2025 :

204 USD

product details :

Irreversible inhibitor of TNF- -induced I B phosphorylation

alt names :

Bay 11-7083

more info or order :

Tocris Bioscience product webpage