product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Bay 11-7085
catalog :
1743/10
quantity :
10 mg
price :
204 USD
more info or order :
Tocris Bioscience product webpage
citations: 9
Reference
Li N, Hui H, Bray B, Gonzalez G, Zeller M, Anderson K, et al. METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection. Cell Rep. 2021;35:109091 pubmed publisher
Liang Y, Xing X, Beamer M, Swindell W, Sarkar M, Roberts L, et al. Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders. J Allergy Clin Immunol. 2017;139:1217-1227 pubmed publisher
Pinte S, Caetano B, Le Bras A, Havet C, Villain G, Dernayka R, et al. Endothelial Cell Activation Is Regulated by Epidermal Growth Factor-like Domain 7 (Egfl7) during Inflammation. J Biol Chem. 2016;291:24017-24028 pubmed
Kwon O, Zhang L, Wang J, Su Q, Feng Q, Zhang X, et al. Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. J Clin Invest. 2016;126:2626-41 pubmed publisher
Clark P, Kim R, Pober J, Kluger M. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases. PLoS ONE. 2015;10:e0120075 pubmed publisher
Kwon O, Valdez J, Zhang L, Zhang B, Wei X, Su Q, et al. Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells. Nat Commun. 2014;5:4416 pubmed publisher
Przybyla L, Theunissen T, Jaenisch R, Voldman J. Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells. 2013;31:1097-106 pubmed publisher
Balzarolo M, Karrich J, Engels S, Blom B, Medema J, Wolkers M. The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs. Eur J Immunol. 2012;42:3019-27 pubmed publisher
Hussain A, Ahmed S, Ahmed M, Khan O, Al Abdulmohsen S, Platanias L, et al. Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis. PLoS ONE. 2012;7:e39945 pubmed publisher
product information
brand :
Tocris
catalog number base :
1743
SKU :
1743/10
product name :
Bay 11-7085
units size :
10 mg
description :
Irreversible inhibitor of TNF- -induced I B phosphorylation
target :
NFkB/IkB Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
249.33
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Bay 11-7085 is an irreversible inhibitor of TNF- -stimulated I B phosphorylation (IC50 ~ 10 u M); leads to decreased NF- B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo .
top caption :
Irreversible inhibitor of TNF- -induced I B phosphorylation
extended description :
Irreversible inhibitor of TNF- -induced I B phosphorylation
chemical name text :
(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
formula :
C13H15NO2S
formula text :
C13H15NO2S
cas num :
196309-76-9
USD :
204 USD
product details :
Irreversible inhibitor of TNF- -induced I B phosphorylation
alt names :
Bay 11-7083
storage :
Store at +4°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK