R-96544 hydrochloride | Tocris Bioscience 1742/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

R-96544 hydrochloride

catalog :

1742/10

quantity :

10 mg (also 50 mg)

price :

243 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Chien C, Su M. 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. J Biomed Sci. 2015;22:42 pubmed publisher
Tanaka T, Doe J, Horstmann S, Ahmad S, Ahmad A, Min S, et al. Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells. J Biol Chem. 2014;289:10466-75 pubmed publisher
Xu Z, Yang Q, Ma L, Liu S, Chen G, Wu Y, et al. Deficits in LTP induction by 5-HT2A receptor antagonist in a mouse model for fragile X syndrome. PLoS ONE. 2012;7:e48741 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1742

SKU :

1742/10

product name :

R-96544 hydrochloride

description :

Potent, selective 5-HT2A antagonist

target :

5-HT2A Receptor Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at RT

observed molecular weight :

391.94

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

R-96544 hydrochloride is a potent, selective 5-HT2 receptor antagonist; displays some selectivity for 5-HT2A receptors (Ki = 1.6 nM). IC50 values are 2.2, 310, 2400, 3700, 5000 and 5000 nM for 5-HT2, 1-adrenergic, D2 dopamine, 5-HT1, 5-HT3 and -adrenergic receptors respectively. Inhibits 5-HT-induced platelet aggregation and pressor responses in vivo .

product keywords :

Potent selective 5-HT2A antagonists serotonin receptors 5-HT2 antagonist 5-HT2A Receptors 1742,

extended description :

Potent, selective 5-HT2A antagonist

chemical name text :

(2R,4R)-5-[2-[2-[2-(3-Methoxyphenyl)ethyl]phenoxy]ethyl]-1-methyl-3-pyrrolidinol hydrochloride

formula :

C22H29NO3.HCl

formula text :

C22H29NO3.HCl

cas num :

167144-80-1

USD :

240

USD 2025 :

243 USD

product details :

Potent, selective 5-HT2A antagonist

more info or order :

Tocris Bioscience product webpage