Indomethacin | Tocris Bioscience 1708/100 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Indomethacin

catalog :

1708/100

quantity :

100 mg

price :

137 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Wheat W, Chow L, Kurihara J, Regan D, Coy J, WEBB T, et al. Suppression of Canine Dendritic Cell Activation/Maturation and Inflammatory Cytokine Release by Mesenchymal Stem Cells Occurs Through Multiple Distinct Biochemical Pathways. Stem Cells Dev. 2017;26:249-262 pubmed publisher
Allen C, Tinganelli W, Sharma N, Nie J, Sicard C, Natale F, et al. DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation. Front Oncol. 2015;5:260 pubmed publisher
Gonnermann D, Oberg H, Kellner C, Peipp M, Sebens S, Kabelitz D, et al. Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against Î³Î´ T cell cytotoxicity. Oncoimmunology. 2015;4:e988460 pubmed
Cramer S, Popa L, Carter R, Chen G, Ebner T. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. J Neurosci. 2015;35:5664-79 pubmed publisher
Tang F, Lane S, Korsak A, Paton J, Gourine A, Kasparov S, et al. Lactate-mediated glia-neuronal signalling in the mammalian brain. Nat Commun. 2014;5:3284 pubmed publisher
Miller R, Tran P, Das R, Ghoreishi Haack N, Ren D, Miller R, et al. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A. 2012;109:20602-7 pubmed publisher
Flamm M, Colace T, Chatterjee M, Jing H, Zhou S, Jaeger D, et al. Multiscale prediction of patient-specific platelet function under flow. Blood. 2012;120:190-8 pubmed publisher

product information

brand :

Tocris

catalog number base :

1708

SKU :

1708/100

product name :

Indomethacin

units size :

100 mg

description :

Cyclooxygenase inhibitor (COX-1 COX-2)

target :

Cyclooxygenase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

357.79

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Indomethacin is a cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2.

top caption :

Cyclooxygenase inhibitor (COX-1 COX-2)

extended description :

Cyclooxygenase inhibitor (COX-1 COX-2)

chemical name text :

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole

formula :

C19H16ClNO4

formula text :

C19H16ClNO4

cas num :

53-86-1

USD :

137 USD

product details :

Cyclooxygenase inhibitor (COX-1 COX-2)

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage