product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
2-Chloro-N6-cyclopentyladenosine
catalog :
1705
quantity :
10 mg (also 50 mg)
price :
159 USD
more info or order :
citations: 11
Reference
Fabera P, Parizkova M, Uttl L, Vondrakova K, Kubova H, Tsenov G, et al. Adenosine A1 Receptor Agonist 2-chloro-N6-cyclopentyladenosine and Hippocampal Excitability During Brain Development in Rats. Front Pharmacol. 2019;10:656 pubmed publisher
Loram L, Taylor F, Strand K, Harrison J, Rzasalynn R, Sholar P, et al. Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling. Brain Behav Immun. 2013;33:112-22 pubmed publisher
Goldman N, Chandler Militello D, Langevin H, Nedergaard M, Takano T. Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts. Cell Calcium. 2013;53:297-301 pubmed publisher
Wu M, Sahbaie P, Zheng M, Lobato R, Boison D, Clark J, et al. Opiate-induced changes in brain adenosine levels and narcotic drug responses. Neuroscience. 2013;228:235-42 pubmed publisher
Hamby M, Coppola G, Ao Y, Geschwind D, Khakh B, Sofroniew M. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. J Neurosci. 2012;32:14489-510 pubmed publisher
Crawford D, Jiang X, Taylor A, Mennerick S. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro. J Neurosci. 2012;32:13100-10 pubmed
Park S, Kim M, Kim J, Brown K, Haase V, D Agati V, et al. Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int. 2012;82:878-91 pubmed publisher
Carman A, Mills J, Krenz A, Kim D, Bynoe M. Adenosine receptor signaling modulates permeability of the blood-brain barrier. J Neurosci. 2011;31:13272-80 pubmed publisher
Ru F, Surdenikova L, Brozmanova M, Kollarik M. Adenosine-induced activation of esophageal nociceptors. Am J Physiol Gastrointest Liver Physiol. 2011;300:G485-93 pubmed publisher
Long X, Mokelke E, Neeb Z, Alloosh M, Edwards J, Sturek M. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine. J Pharmacol Exp Ther. 2010;335:781-7 pubmed publisher
Keene A, Balasubramanian R, Lloyd J, Shainberg A, Jacobson K. Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor. Biochem Pharmacol. 2010;80:188-96 pubmed publisher
product information
brand :
Tocris
master code :
1705
SKU :
1705/10
product name :
2-Chloro-N6-cyclopentyladenosine
description :
Potent, selective A1 agonist
target :
Adenosine A1 Receptor Agonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
369.81
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent and selective adenosine A1 receptor agonist (Ki values are 0.8, 2300 and 42 nM for human A1, A2A and A3 receptors respectively; EC50 = 18800 nM for hA2B). Centrally active following systemic administration in vivo .
catalog number base :
1705
product keywords :
Potent selective A1 agonists Receptors adenosines CCPA Adenosine A1 Receptors 1705,
extended description :
Potent, selective A1 agonist
chemical name text :
2-Chloro-N-cyclopentyladenosine
formula :
C 15 H 20 ClN 5 O 4
formula text :
C15H20ClN5O4
cas num :
37739-05-2
2020 USD :
152
2021 USD :
159 USD
alt names :
CCPA
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK