2-Chloro-N6-cyclopentyladenosine | Tocris Bioscience 1705/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

2-Chloro-N6-cyclopentyladenosine

catalog :

1705/10

quantity :

10 mg (also 50 mg)

price :

200 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Fabera P, Parizkova M, Uttl L, Vondrakova K, Kubova H, Tsenov G, et al. Adenosine A1 Receptor Agonist 2-chloro-N6-cyclopentyladenosine and Hippocampal Excitability During Brain Development in Rats. Front Pharmacol. 2019;10:656 pubmed publisher
Subramanian M, Kini R, Madasu M, Ohta A, Nowak M, Exley M, et al. Extracellular adenosine controls NKT-cell-dependent hepatitis induction. Eur J Immunol. 2014;44:1119-29 pubmed publisher
Loram L, Taylor F, Strand K, Harrison J, Rzasalynn R, Sholar P, et al. Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling. Brain Behav Immun. 2013;33:112-22 pubmed publisher
Goldman N, Chandler Militello D, Langevin H, Nedergaard M, Takano T. Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts. Cell Calcium. 2013;53:297-301 pubmed publisher
Wu M, Sahbaie P, Zheng M, Lobato R, Boison D, Clark J, et al. Opiate-induced changes in brain adenosine levels and narcotic drug responses. Neuroscience. 2013;228:235-42 pubmed publisher
Hamby M, Coppola G, Ao Y, Geschwind D, Khakh B, Sofroniew M. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. J Neurosci. 2012;32:14489-510 pubmed publisher
Crawford D, Jiang X, Taylor A, Mennerick S. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro. J Neurosci. 2012;32:13100-10 pubmed
Park S, Kim M, Kim J, Brown K, Haase V, D Agati V, et al. Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int. 2012;82:878-91 pubmed publisher
Carman A, Mills J, Krenz A, Kim D, Bynoe M. Adenosine receptor signaling modulates permeability of the blood-brain barrier. J Neurosci. 2011;31:13272-80 pubmed publisher
Ru F, Surdenikova L, Brozmanova M, Kollarik M. Adenosine-induced activation of esophageal nociceptors. Am J Physiol Gastrointest Liver Physiol. 2011;300:G485-93 pubmed publisher
Long X, Mokelke E, Neeb Z, Alloosh M, Edwards J, Sturek M. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine. J Pharmacol Exp Ther. 2010;335:781-7 pubmed publisher
Keene A, Balasubramanian R, Lloyd J, Shainberg A, Jacobson K. Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor. Biochem Pharmacol. 2010;80:188-96 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1705

SKU :

1705/10

product name :

2-Chloro-N6-cyclopentyladenosine

description :

Potent and selective A1 agonist

target :

Adenosine A1 Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at RT

observed molecular weight :

369.81

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

2-Chloro-N6-cyclopentyladenosine is a potent and selective adenosine A1 receptor agonist (Ki values are 0.8, 2300 and 42 nM for human A1, A2A and A3 receptors respectively; EC50 = 18800 nM for hA2B). Centrally active following systemic administration in vivo .

product keywords :

Potent selective A1 agonists Receptors adenosines CCPA Adenosine A1 Receptors 1705,

extended description :

Potent and selective A1 agonist

chemical name text :

2-Chloro-N-cyclopentyladenosine

formula :

C15H20ClN5O4

formula text :

C15H20ClN5O4

cas num :

37739-05-2

USD :

198

USD 2025 :

200 USD

product details :

Potent and selective A1 agonist

alt names :

CCPA

more info or order :

Tocris Bioscience product webpage