A 77636 hydrochloride | Tocris Bioscience 1701 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 77636 hydrochloride

catalog :

1701

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Lee J, Nam J, Nam Y, Nam H, Yoon G, Ko E, et al. The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD. J Neuroinflammation. 2018;15:286 pubmed publisher
Chai H, Diaz Castro B, Shigetomi E, Monte E, Octeau J, Yu X, et al. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. 2017;95:531-549.e9 pubmed publisher
Zalocusky K, Ramakrishnan C, Lerner T, Davidson T, Knutson B, Deisseroth K. Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making. Nature. 2016;531:642-6 pubmed publisher
Guha S, Baltazar G, Tu L, Liu J, Lim J, Lu W, et al. Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem. 2012;122:823-33 pubmed publisher
Chan J, Vuckovic D, Sleno L, Olsen J, Pogoutse O, Havugimana P, et al. Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization. Mol Cell Proteomics. 2012;11:M111.016642 pubmed publisher

product information

brand :

Tocris

master code :

1701

SKU :

1701/10

product name :

A 77636 hydrochloride

description :

Potent and selective D1-like agonist; orally active

target :

Dopamine D1 and D5 Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

365.9

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo . Exhibits 11-fold cell type bias over dopamine in a functional assay in U2 cells.

catalog number base :

1701

product keywords :

Potent selective D1-like agonists Orally active Dopamine D1 Receptors D5 dopaminergic A77636 hydrochloride biased agonism D1 and D5 Receptors 1701,

extended description :

Potent and selective D1-like agonist; orally active

chemical name text :

(1R-cis)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diol hydrochloride

formula :

C 20 H 27 NO 3 .HCl

formula text :

C20H27NO3.HCl

cas num :

145307-34-2

2020 USD :

207

2021 USD :

216 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage