A 77636 hydrochloride | Tocris Bioscience 1701/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 77636 hydrochloride

catalog :

1701/10

quantity :

10 mg (also 50 mg)

price :

271 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Lee J, Nam J, Nam Y, Nam H, Yoon G, Ko E, et al. The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD. J Neuroinflammation. 2018;15:286 pubmed publisher
Chai H, Diaz Castro B, Shigetomi E, Monte E, Octeau J, Yu X, et al. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. 2017;95:531-549.e9 pubmed publisher
Minami K, Liu S, Liu Y, Chen A, Wan Q, Na S, et al. Inhibitory Effects of Dopamine Receptor D1 Agonist on Mammary Tumor and Bone Metastasis. Sci Rep. 2017;7:45686 pubmed publisher
Zalocusky K, Ramakrishnan C, Lerner T, Davidson T, Knutson B, Deisseroth K. Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making. Nature. 2016;531:642-6 pubmed publisher
Guha S, Baltazar G, Tu L, Liu J, Lim J, Lu W, et al. Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem. 2012;122:823-33 pubmed publisher
Chan J, Vuckovic D, Sleno L, Olsen J, Pogoutse O, Havugimana P, et al. Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization. Mol Cell Proteomics. 2012;11:M111.016642 pubmed publisher

product information

brand :

Tocris

catalog number base :

1701

SKU :

1701/10

product name :

A 77636 hydrochloride

units size :

10 mg (also 50 mg)

description :

Potent and selective D1-like agonist; orally active

target :

Dopamine D1 and D5 Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

365.9

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A 77636 hydrochloride is a potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo . Exhibits 11-fold cell type bias over dopamine in a functional assay in U2 cells.

top caption :

Potent and selective D1-like agonist; orally active

extended description :

Potent and selective D1-like agonist; orally active

chemical name text :

(1R-cis)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diol hydrochloride

formula :

C20H27NO3.HCl

formula text :

C20H27NO3.HCl

cas num :

145307-34-2

USD :

271 USD

product details :

Potent and selective D1-like agonist; orally active

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage