This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Tocris Bioscience
product type :
chemical
product name :
BIIE 0246
catalog :
1700
quantity :
1 mg (also 10 mg)
price :
171 USD
citations: 26
Reference
Businaro R, Scaccia E, Bordin A, Pagano F, Corsi M, Siciliano C, et al. Platelet Lysate-Derived Neuropeptide y Influences Migration and Angiogenesis of Human Adipose Tissue-Derived Stromal Cells. Sci Rep. 2018;8:14365 pubmed publisher
Martins J, Elvas F, Brudzewsky D, Martins T, Kolomiets B, Tralhão P, et al. Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro. ASN Neuro. 2015;7: pubmed publisher
Alasvand M, Rashidi B, Haghjooy Javanmard S, Khazaei M. Effect of blockade of neuropeptide Y receptor on aortic intima-media thickness and adipose tissue characteristics in normal and obese mice. Iran J Basic Med Sci. 2015;18:443-8 pubmed
Aveleira C, Botelho M, Carmo Silva S, Pascoal J, Ferreira Marques M, Nóbrega C, et al. Neuropeptide Y stimulates autophagy in hypothalamic neurons. Proc Natl Acad Sci U S A. 2015;112:E1642-51 pubmed publisher
Pleil K, Rinker J, Lowery Gionta E, Mazzone C, McCall N, Kendra A, et al. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci. 2015;18:545-52 pubmed publisher
Panaro B, Tough I, Engelstoft M, Matthews R, Digby G, Møller C, et al. The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. Cell Metab. 2014;20:1018-29 pubmed publisher
Tilan J, Lu C, Galli S, Izycka Swieszewska E, Earnest J, Shabbir A, et al. Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects. Oncotarget. 2013;4:2487-501 pubmed
Chandarana K, Gelegen C, Irvine E, Choudhury A, Amouyal C, Andreelli F, et al. Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance. Mol Metab. 2013;2:142-52 pubmed publisher
Santos Carvalho A, Elvas F, Alvaro A, Ambrósio A, Cavadas C. Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate. Cell Death Dis. 2013;4:e636 pubmed publisher
REIDELBERGER R, Haver A, Chelikani P. Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats. Am J Physiol Endocrinol Metab. 2013;304:E944-50 pubmed publisher
Atasoy D, Betley J, Su H, Sternson S. Deconstruction of a neural circuit for hunger. Nature. 2012;488:172-7 pubmed publisher
Kojima S, Tohei A, Anzai N. A role for endogenous peptide YY in tachykinin NK(2) receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol. 2012;167:1362-8 pubmed publisher
Han R, Kitlinska J, Munday W, Gallicano G, Zukowska Z. Stress hormone epinephrine enhances adipogenesis in murine embryonic stem cells by up-regulating the neuropeptide Y system. PLoS ONE. 2012;7:e36609 pubmed publisher
Chen Z, Travers S, Travers J. Activation of NPY receptors suppresses excitatory synaptic transmission in a taste-feeding network in the lower brain stem. Am J Physiol Regul Integr Comp Physiol. 2012;302:R1401-10 pubmed publisher
Sparrow A, Lowery Gionta E, Pleil K, Li C, Sprow G, Cox B, et al. Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Neuropsychopharmacology. 2012;37:1409-21 pubmed publisher
Herring N, Cranley J, Lokale M, Li D, Shanks J, Alston E, et al. The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability. J Mol Cell Cardiol. 2012;52:667-76 pubmed publisher
Ferreira R, Santos T, Viegas M, Cortes L, Bernardino L, Vieira O, et al. Neuropeptide Y inhibits interleukin-1?-induced phagocytosis by microglial cells. J Neuroinflammation. 2011;8:169 pubmed publisher
Demorrow S, Onori P, Venter J, Invernizzi P, Frampton G, White M, et al. Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion. Am J Physiol Cell Physiol. 2011;300:C1078-89 pubmed publisher
Ferreira R, Xapelli S, Santos T, Silva A, Cristóvão A, Cortes L, et al. Neuropeptide Y modulation of interleukin-1{beta} (IL-1{beta})-induced nitric oxide production in microglia. J Biol Chem. 2010;285:41921-34 pubmed publisher
Woldbye D, Angehagen M, Gøtzsche C, Elbrønd Bek H, Sørensen A, Christiansen S, et al. Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures. Brain. 2010;133:2778-88 pubmed publisher
Pickens C, Adams Deutsch T, Nair S, Navarre B, Heilig M, Shaham Y. Effect of pharmacological manipulations of neuropeptide Y and corticotropin-releasing factor neurotransmission on incubation of conditioned fear. Neuroscience. 2009;164:1398-406 pubmed publisher
Rose J, Crews L, Rockenstein E, Adame A, Mante M, Hersh L, et al. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci. 2009;29:1115-25 pubmed publisher
Hao S, Sternini C, Raybould H. Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligands. Am J Physiol Regul Integr Comp Physiol. 2008;294:R33-8 pubmed
Ghitza U, Nair S, Golden S, Gray S, Uejima J, Bossert J, et al. Peptide YY3-36 decreases reinstatement of high-fat food seeking during dieting in a rat relapse model. J Neurosci. 2007;27:11522-32 pubmed
Ortiz A, Milardo L, DeCarr L, Buckholz T, Mays M, Claus T, et al. A novel long-acting selective neuropeptide Y2 receptor polyethylene glycol-conjugated peptide agonist reduces food intake and body weight and improves glucose metabolism in rodents. J Pharmacol Exp Ther. 2007;323:692-700 pubmed
Sah R, Parker S, Sheriff S, Eaton K, Balasubramaniam A, Sallee F. Interaction of NPY compounds with the rat glucocorticoid-induced receptor (GIR) reveals similarity to the NPY-Y2 receptor. Peptides. 2007;28:302-9 pubmed
product information
brand :
Tocris
master code :
1700
SKU :
1700/1
product name :
BIIE 0246
description :
Potent, selective non-peptide NPY Y2 receptor antagonist
target :
NPY Receptor Antagonists
category :
Small Molecules
unit size :
1 mg (also 10 mg)
purity :
98%
observed molecular weight :
896.06
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays 650-fold selectivity over Y1, Y4 and Y5 receptors. Active in vivo .
catalog number base :
1700
product keywords :
Potent selective non-peptide NPY Y2 antagonists Neuropeptide Y Receptors BIIE0246 neuropeptides NPY Receptors 1700,
extended description :
Potent, selective non-peptide NPY Y2 receptor antagonist
chemical name text :
N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide
formula :
C 49 H 57 N 11 O 6
formula text :
C49H57N11O6
cas num :
246146-55-4
2020 USD :
167
2021 USD :
171 USD
storage :
Store at +4°C
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK