This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Tocris Bioscience
product type :
chemical
product name :
BIIE 0246
catalog :
1700
quantity :
1 mg (also 10 mg)
price :
171 USD
citations: 26
Reference |
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Alasvand M, Rashidi B, Haghjooy Javanmard S, Khazaei M. Effect of blockade of neuropeptide Y receptor on aortic intima-media thickness and adipose tissue characteristics in normal and obese mice. Iran J Basic Med Sci. 2015;18:443-8 pubmed
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Tilan J, Lu C, Galli S, Izycka Swieszewska E, Earnest J, Shabbir A, et al. Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects. Oncotarget. 2013;4:2487-501 pubmed
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Hao S, Sternini C, Raybould H. Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligands. Am J Physiol Regul Integr Comp Physiol. 2008;294:R33-8 pubmed
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Ghitza U, Nair S, Golden S, Gray S, Uejima J, Bossert J, et al. Peptide YY3-36 decreases reinstatement of high-fat food seeking during dieting in a rat relapse model. J Neurosci. 2007;27:11522-32 pubmed
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Ortiz A, Milardo L, DeCarr L, Buckholz T, Mays M, Claus T, et al. A novel long-acting selective neuropeptide Y2 receptor polyethylene glycol-conjugated peptide agonist reduces food intake and body weight and improves glucose metabolism in rodents. J Pharmacol Exp Ther. 2007;323:692-700 pubmed
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Sah R, Parker S, Sheriff S, Eaton K, Balasubramaniam A, Sallee F. Interaction of NPY compounds with the rat glucocorticoid-induced receptor (GIR) reveals similarity to the NPY-Y2 receptor. Peptides. 2007;28:302-9 pubmed
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product information
brand :
Tocris
master code :
1700
SKU :
1700/1
product name :
BIIE 0246
description :
Potent, selective non-peptide NPY Y2 receptor antagonist
target :
NPY Receptor Antagonists
category :
Small Molecules
unit size :
1 mg (also 10 mg)
purity :
98%
observed molecular weight :
896.06
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays 650-fold selectivity over Y1, Y4 and Y5 receptors. Active in vivo .
catalog number base :
1700
product keywords :
Potent selective non-peptide NPY Y2 antagonists Neuropeptide Y Receptors BIIE0246 neuropeptides NPY Receptors 1700,
extended description :
Potent, selective non-peptide NPY Y2 receptor antagonist
chemical name text :
N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide
formula :
C 49 H 57 N 11 O 6
formula text :
C49H57N11O6
cas num :
246146-55-4
2020 USD :
167
2021 USD :
171 USD
storage :
Store at +4°C
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
questions and comments