BIIE 0246 | Tocris Bioscience 1700/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BIIE 0246

catalog :

1700/10

quantity :

10 mg

price :

339 USD

citations: 21

Reference
Martins J, Elvas F, Brudzewsky D, Martins T, Kolomiets B, TralhÃ£o P, et al. Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro. ASN Neuro. 2015;7: pubmed publisher
Alasvand M, Rashidi B, Haghjooy Javanmard S, Khazaei M. Effect of blockade of neuropeptide Y receptor on aortic intima-media thickness and adipose tissue characteristics in normal and obese mice. Iran J Basic Med Sci. 2015;18:443-8 pubmed
Aveleira C, Botelho M, Carmo Silva S, Pascoal J, Ferreira Marques M, NÃ³brega C, et al. Neuropeptide Y stimulates autophagy in hypothalamic neurons. Proc Natl Acad Sci U S A. 2015;112:E1642-51 pubmed publisher
Pleil K, Rinker J, Lowery Gionta E, Mazzone C, McCall N, Kendra A, et al. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci. 2015;18:545-52 pubmed publisher
Panaro B, Tough I, Engelstoft M, Matthews R, Digby G, MÃ¸ller C, et al. The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. Cell Metab. 2014;20:1018-29 pubmed publisher
Tilan J, Lu C, Galli S, Izycka Swieszewska E, Earnest J, Shabbir A, et al. Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects. Oncotarget. 2013;4:2487-501 pubmed
Santos Carvalho A, Elvas F, Alvaro A, Ambrósio A, Cavadas C. Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate. Cell Death Dis. 2013;4:e636 pubmed publisher
REIDELBERGER R, Haver A, Chelikani P. Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats. Am J Physiol Endocrinol Metab. 2013;304:E944-50 pubmed publisher
Atasoy D, Betley J, Su H, Sternson S. Deconstruction of a neural circuit for hunger. Nature. 2012;488:172-7 pubmed publisher
Kojima S, Tohei A, Anzai N. A role for endogenous peptide YY in tachykinin NK(2) receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol. 2012;167:1362-8 pubmed publisher
Han R, Kitlinska J, Munday W, Gallicano G, Zukowska Z. Stress hormone epinephrine enhances adipogenesis in murine embryonic stem cells by up-regulating the neuropeptide Y system. PLoS ONE. 2012;7:e36609 pubmed publisher
Chen Z, Travers S, Travers J. Activation of NPY receptors suppresses excitatory synaptic transmission in a taste-feeding network in the lower brain stem. Am J Physiol Regul Integr Comp Physiol. 2012;302:R1401-10 pubmed publisher
Sparrow A, Lowery Gionta E, Pleil K, Li C, Sprow G, Cox B, et al. Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Neuropsychopharmacology. 2012;37:1409-21 pubmed publisher
Ferreira R, Santos T, Viegas M, Cortes L, Bernardino L, Vieira O, et al. Neuropeptide Y inhibits interleukin-1?-induced phagocytosis by microglial cells. J Neuroinflammation. 2011;8:169 pubmed publisher
Demorrow S, Onori P, Venter J, Invernizzi P, Frampton G, White M, et al. Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion. Am J Physiol Cell Physiol. 2011;300:C1078-89 pubmed publisher
Ferreira R, Xapelli S, Santos T, Silva A, Cristóvão A, Cortes L, et al. Neuropeptide Y modulation of interleukin-1{beta} (IL-1{beta})-induced nitric oxide production in microglia. J Biol Chem. 2010;285:41921-34 pubmed publisher
Pickens C, Adams Deutsch T, Nair S, Navarre B, Heilig M, Shaham Y. Effect of pharmacological manipulations of neuropeptide Y and corticotropin-releasing factor neurotransmission on incubation of conditioned fear. Neuroscience. 2009;164:1398-406 pubmed publisher
Rose J, Crews L, Rockenstein E, Adame A, Mante M, Hersh L, et al. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci. 2009;29:1115-25 pubmed publisher
Ghitza U, Nair S, Golden S, Gray S, Uejima J, Bossert J, et al. Peptide YY3-36 decreases reinstatement of high-fat food seeking during dieting in a rat relapse model. J Neurosci. 2007;27:11522-32 pubmed
Ortiz A, Milardo L, DeCarr L, Buckholz T, Mays M, Claus T, et al. A novel long-acting selective neuropeptide Y2 receptor polyethylene glycol-conjugated peptide agonist reduces food intake and body weight and improves glucose metabolism in rodents. J Pharmacol Exp Ther. 2007;323:692-700 pubmed
Sah R, Parker S, Sheriff S, Eaton K, Balasubramaniam A, Sallee F. Interaction of NPY compounds with the rat glucocorticoid-induced receptor (GIR) reveals similarity to the NPY-Y2 receptor. Peptides. 2007;28:302-9 pubmed

product information

CHEMISTRY :

O=C(C4=C3C=CC=C4)NC1=CC=CC=C1C3N(CC2)CCN2C(CC5(CCCC5)CC(N[C@@H](CCCNC(N)=N)C(NCCN6C(N(C7=CC=CC=C7)N(C8=CC=CC=C8)C6=O)=O)=O)=O)=O

Stock Reference :

1700/10

Cat Number :

1700

Product Name :

BIIE 0246

Cas Number :

[246146-55-4]

Unit Size :

10 mg

Size :

Unit :

USD :

339 USD

Primary Category :

7-TM Receptors

Secondary Category :

Peptide Receptors

Tertiary Category :

NPY Receptors

Primary Action :

Potent, selective non-peptide NPY Y2 receptor antagonist

Biological Description :

Potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays > 650-fold selectivity over Y1, Y4 and Y5 receptors. Active in vivo.

Storage :

Store at +4°C

Formula :

C49H57N11O6

Molwt :

896.06

Minimum Purity :

> 98%

Solubility :

Soluble to 25 mM in ethanol and to 75 mM in DMSO

RTECS No :

GY2400000