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company name :
Tocris Bioscience
product type :
chemical
product name :
NECA
catalog :
1691/10
quantity :
10 mg (also 50 mg)
price :
89 USD
more info or order :
citations: 27
Reference
Klysz D, Fowler C, Malipatlolla M, Stuani L, Freitas K, Chen Y, et al. Inosine induces stemness features in CAR-T cells and enhances potency. Cancer Cell. 2024;42:266-282.e8 pubmed publisher
Akoume M, Elbakry M, Veillette M, Franco A, Nada D, Labelle H, et al. A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep. 2019;9:10074 pubmed publisher
Liu G, Zhang W, Guo J, Kong F, Zhou S, Chen S, et al. Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect. Brain Res. 2018;1700:47-55 pubmed publisher
Salimu J, Webber J, Gurney M, Al Taei S, Clayton A, Tabi Z. Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes. J Extracell Vesicles. 2017;6:1368823 pubmed publisher
Chiu D, Tse A, Xu I, Di Cui J, Lai R, Li L, et al. Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma. Nat Commun. 2017;8:517 pubmed publisher
Al Taei S, Salimu J, Spary L, Clayton A, Lester J, Tabi Z. Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer. Oncoimmunology. 2017;6:e1268308 pubmed publisher
Song A, Zhang Y, Han L, Yegutkin G, Liu H, Sun K, et al. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 2017;8:14108 pubmed publisher
Schulz N, Liu K, Charbord J, Mattsson C, Tao L, Tworus D, et al. Critical role for adenosine receptor A2a in ?-cell proliferation. Mol Metab. 2016;5:1138-1146 pubmed publisher
Kim D, Bynoe M. A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. J Clin Invest. 2016;126:1717-33 pubmed publisher
Cohen H, Ward A, Hamidzadeh K, Ravid K, Mosser D. IFN-γ Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response. J Immunol. 2015;195:3828-37 pubmed publisher
Welihinda A, Amento E. Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation. J Inflamm (Lond). 2014;11:37 pubmed publisher
Mahamed D, Toussaint L, Bynoe M. CD73-generated adenosine is critical for immune regulation during Toxoplasma gondii infection. Infect Immun. 2015;83:721-9 pubmed publisher
Kim D, Bynoe M. A2A Adenosine Receptor Regulates the Human Blood-Brain Barrier Permeability. Mol Neurobiol. 2015;52:664-78 pubmed publisher
Poddar N, Zano S, Natarajan R, Yamamoto B, Viola R. Enhanced brain distribution of modified aspartoacylase. Mol Genet Metab. 2014;113:219-24 pubmed publisher
Bertheleme N, Strege A, Bunting S, Dowell S, Byrne B. Arginine 199 and leucine 208 have key roles in the control of adenosine A2A receptor signalling function. PLoS ONE. 2014;9:e89613 pubmed publisher
Koscsó B, Csóka B, Kókai E, Németh Z, Pacher P, Virag L, et al. Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages. J Leukoc Biol. 2013;94:1309-15 pubmed publisher
Aggarwal N, D Alessio F, Eto Y, Chau E, Avalos C, Waickman A, et al. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury. Am J Respir Cell Mol Biol. 2013;48:635-46 pubmed publisher
Bulavina L, Szulzewsky F, Rocha A, Krabbe G, Robson S, Matyash V, et al. NTPDase1 activity attenuates microglial phagocytosis. Purinergic Signal. 2013;9:199-205 pubmed publisher
Kinsey G, Huang L, Jaworska K, Khutsishvili K, Becker D, Ye H, et al. Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection. J Am Soc Nephrol. 2012;23:1528-37 pubmed publisher
Carman A, Mills J, Krenz A, Kim D, Bynoe M. Adenosine receptor signaling modulates permeability of the blood-brain barrier. J Neurosci. 2011;31:13272-80 pubmed publisher
Pedroza M, Schneider D, Karmouty Quintana H, Coote J, Shaw S, Corrigan R, et al. Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury. PLoS ONE. 2011;6:e22667 pubmed publisher
Gomez G, Zhao W, Schwartz L. Disparity in Fc?RI-induced degranulation of primary human lung and skin mast cells exposed to adenosine. J Clin Immunol. 2011;31:479-87 pubmed publisher
Jin D, Fan J, Wang L, Thompson L, Liu A, Daniel B, et al. CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression. Cancer Res. 2010;70:2245-55 pubmed publisher
Garavaglia A, Moiana A, Camnasio S, Bolognini D, Papait R, Rigamonti D, et al. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci. 2010;11:7 pubmed publisher
Clark B, Kurth Nelson Z, Newman E. Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation. J Neurosci. 2009;29:11237-45 pubmed publisher
Xi J, McIntosh R, Shen X, Lee S, Chanoit G, Criswell H, et al. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol. 2009;47:684-90 pubmed publisher
Newman E. Calcium increases in retinal glial cells evoked by light-induced neuronal activity. J Neurosci. 2005;25:5502-10 pubmed
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
1691
SKU :
1691/10
product name :
NECA
description :
High affinity adenosine agonist
target :
Non-selective Adenosine Receptor Agonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Store at +4°C
observed molecular weight :
308.3
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
NECA is a high affinity adenosine receptor agonist (Ki values are 6.2, 14, and 20 nM for human A3, A1 and A2A receptors respectively; EC50 = 2.4 u M for human A2B). Inhibits platelet aggregation and is centrally active in vivo .
product keywords :
adenosines receptor agonists Non-Selective Receptors 5-N-Ethylcarboxamidoadenosine 5'-N-Ethylcarboxamidoadenosine Non-selective Adenosine 1691,
extended description :
High affinity adenosine agonist
chemical name text :
1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl- -D-ribofuranuronamide
formula :
C12H16N6O4
formula text :
C12H16N6O4
cas num :
35920-39-9
USD :
85
USD 2025 :
89 USD
product details :
High affinity adenosine agonist
alt names :
5 - N -Ethylcarboxamidoadenosine
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK