K 252a | Tocris Bioscience 1683/200U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

K 252a

catalog :

1683/200U

quantity :

200 ug

price :

339 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Martín Segura A, Casadomé Perales Á, Fazzari P, Mas J, Artigas L, Valls R, et al. Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism. Front Neurol. 2019;10:675 pubmed publisher
Van Kummer B, Cohen R. Exercise-induced neuroprotection in the spastic Han Wistar rat: the possible role of brain-derived neurotrophic factor. Biomed Res Int. 2015;2015:834543 pubmed publisher
Schubert M, Panja D, Haugen M, Bramham C, Vedeler C. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol. 2014;128:835-52 pubmed publisher
Pandya C, Pillai A. TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis. Cell Commun Signal. 2014;12:47 pubmed publisher
Chen W, Walwyn W, Ennes H, Kim H, McRoberts J, Marvizon J. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci. 2014;39:1439-54 pubmed publisher
Park S, Shin E, Min S, An J, Li Z, Hee Chung Y, et al. Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Neuropsychopharmacology. 2013;38:1426-37 pubmed publisher
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed publisher

product information

brand :

Tocris

master code :

1683

SKU :

1683/200U

product name :

K 252a

description :

Protein kinase inhibitor

target :

Broad Spectrum Protein Kinase Inhibitors

category :

Small Molecules

unit sizes :

200 ug

purity :

98%

observed molecular weight :

467.48

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

K 252a is a non-selective protein kinase inhibitor; analog of staurosporine (Cat.No. 1285). Inhibits PKC (IC50 = 32.9 nM), Ca2+/calmodulin-stimulated phosphodiesterases (IC50 = 1.3 - 2.9 u M), MLCK (Ki = 20 nM) and receptor tyrosine kinases. Inhibits the oncogenic properties of MET; prevents autophosphorylation and activation of downstream effectors (MAPK, Akt).

extended description :

Protein kinase inhibitor

chemical name text :

(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3 ,2 ,1 -kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester

formula :

C 27 H 21 N 3 O 5

formula text :

C27H21N3O5

cas num :

99533-80-9

USD :

339 USD

product details :

Protein kinase inhibitor

alt names :

SF 2370

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage