GW 7647 | Tocris Bioscience 1677 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GW 7647

catalog :

1677

quantity :

10 mg (also 50 mg)

price :

270 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Fellous T, De Maio F, Kalkan H, Carannante B, Boccella S, Petrosino S, et al. Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets. Biochem Pharmacol. 2020;175:113859 pubmed publisher
Guo B, Huang X, Lee M, Lee S, Broxmeyer H. Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis. Nat Med. 2018;24:360-367 pubmed publisher
Mattsson A, Karrman A, Pinto R, Brunström B. Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA) and Agonists to Peroxisome Proliferator-Activated Receptors. PLoS ONE. 2015;10:e0143780 pubmed publisher
Moreno Santos I, Pavon F, Romero Cuevas M, Serrano A, Cano C, Suardiaz M, et al. Computational and biological evaluation of N-octadecyl-N'-propylsulfamide, a selective PPAR? agonist structurally related to N-acylethanolamines. PLoS ONE. 2014;9:e92195 pubmed publisher
Yu D, Lin W, Chen T, Forman B. Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery. Bioorg Med Chem. 2013;21:4266-78 pubmed publisher
Mottillo E, Bloch A, Leff T, Granneman J. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply. J Biol Chem. 2012;287:25038-48 pubmed publisher
Hatano Y, Man M, Uchida Y, Crumrine D, Mauro T, Feingold K, et al. Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators. J Allergy Clin Immunol. 2010;125:160-9.e1-5 pubmed publisher
Ropero A, Juan Pico P, Rafacho A, Fuentes E, Bermúdez Silva F, Roche E, et al. Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans. J Endocrinol. 2009;200:127-38 pubmed publisher

product information

brand :

Tocris

master code :

1677

SKU :

1677/10

product name :

GW 7647

description :

Highly selective, potent PPAR agonist. Orally active

target :

PPAR alpha Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

502.75

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and highly selective PPAR agonist (EC50 values are 6, 1100 and 6200 nM for human PPAR , PPAR and PPAR receptors respectively). Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro . Has lipid-lowering effects following oral administration in vivo . Reduces NO production in macrophages; exhibits anti-inflammatory properties.

catalog number base :

1677

product keywords :

selective potent PPAR PPARalpha agonists Orally active Peroxisome Proliferator-activating Receptors PPAR GW7647 GlaxoSmithKline GSK anti-inflammatory PPARalpha Receptors 1677,

extended description :

Highly selective, potent PPAR agonist. Orally active

chemical name text :

2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoic acid

formula :

C 29 H 46 N 2 O 3 S

formula text :

C29H46N2O3S

cas num :

265129-71-3

2020 USD :

259

2021 USD :

270 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage