LE 300 | Tocris Bioscience 1674 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LE 300

catalog :

1674

quantity :

10 mg

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Cilz N, Kurada L, Hu B, Lei S. Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels. Cereb Cortex. 2014;24:3195-208 pubmed publisher
Gildea J, Wang X, Shah N, Tran H, Spinosa M, Van Sciver R, et al. Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells. Hypertension. 2012;60:396-403 pubmed publisher

product information

brand :

Tocris

master code :

1674

SKU :

1674/10

product name :

LE 300

description :

Potent and selective D1 antagonist

target :

Dopamine D1 and D5 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

290.41

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective dopamine D1 receptor antagonist (Ki values are 0.08 - 1.9 nM and 6 - 45 nM for D1 and D2 receptors respectively). Also displays moderate affinity for the 5-HT2A receptor (Ki = 20 nM). Active in vivo .

catalog number base :

1674

product keywords :

Potent selective dopamine D1 antagonists Dopamine Receptors dopaminergic LE300 D1 and D5 Receptors 1674,

extended description :

Potent and selective D1 antagonist

chemical name text :

6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f][3]benzazecine

formula :

C 20 H 22 N 2

formula text :

C20H22N2

cas num :

274694-98-3

2020 USD :

218

2021 USD :

227 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage