RU 28318, potassium salt | Tocris Bioscience 1672 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RU 28318, potassium salt

catalog :

1672

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Sabourin J, Bartoli F, Antigny F, Gomez A, Benitah J. Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES. J Biol Chem. 2016;291:13394-409 pubmed publisher
Dorey R, Pierard C, Chauveau F, David V, Beracochea D. Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus. Neuropsychopharmacology. 2012;37:2870-80 pubmed publisher
Luther J, Luo P, Kreger M, Brissova M, Dai C, Whitfield T, et al. Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets. Diabetologia. 2011;54:2152-63 pubmed publisher
Mayanagi T, Morita T, Hayashi K, Fukumoto K, Sobue K. Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton. J Biol Chem. 2008;283:31183-96 pubmed publisher
Crochemore C, Lu J, Wu Y, Liposits Z, Sousa N, Holsboer F, et al. Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. Mol Psychiatry. 2005;10:790-8 pubmed
Yang C, Huang C, Hsu K. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. J Neurosci. 2005;25:4288-93 pubmed

product information

brand :

Tocris

master code :

1672

SKU :

1672/10

product name :

RU 28318, potassium salt

description :

Potent, selective mineralocorticoid receptor antagonist

target :

Mineralocorticoid Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

440.66

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo .

catalog number base :

1672

product keywords :

Potent selective mineralocorticoid antagonists Aldosterone Receptors RU28318 potassium salt Oxprenoate potassium Mineralocorticoid Receptor 1672,

extended description :

Potent, selective mineralocorticoid receptor antagonist

chemical name text :

(7 ,17 )-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid, potassium salt

formula :

C 25 H 37 O 4 K

formula text :

C25H37O4K

cas num :

76676-34-1

2020 USD :

209

2021 USD :

216 USD

alt names :

Oxprenoate potassium

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage