SB 206553 hydrochloride | Tocris Bioscience 1661/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 206553 hydrochloride

catalog :

1661/10

quantity :

10 mg (also 50 mg)

price :

299 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Li Y, Lucas Osma A, Black S, Bandet M, Stephens M, Vavrek R, et al. Pericytes impair capillary blood flow and motor function after chronic spinal cord injury. Nat Med. 2017;23:733-741 pubmed publisher
Kuo H, Lai Y, Wu J, Lee K, Chu C, Chen I, et al. A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases. Int J Biol Sci. 2013;10:64-72 pubmed publisher
Li Y, Li L, Stephens M, Zenner D, Murray K, Winship I, et al. Synthesis, transport, and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in rats. J Neurophysiol. 2014;111:145-63 pubmed publisher
Bigford G, Chaudhry N, Keane R, Holohean A. 5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-methyl-D-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization. J Biol Chem. 2012;287:11049-59 pubmed publisher
Delaney C, Gien J, Grover T, Roe G, Abman S. Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus. Am J Physiol Lung Cell Mol Physiol. 2011;301:L937-44 pubmed publisher
Fouad K, Rank M, Vavrek R, Murray K, Sanelli L, Bennett D. Locomotion after spinal cord injury depends on constitutive activity in serotonin receptors. J Neurophysiol. 2010;104:2975-84 pubmed publisher
Murray K, Nakae A, Stephens M, Rank M, D Amico J, Harvey P, et al. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med. 2010;16:694-700 pubmed publisher
Canal C, Olaghere da Silva U, Gresch P, Watt E, Sanders Bush E, Airey D. The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen. Psychopharmacology (Berl). 2010;209:163-74 pubmed publisher
Hampson L, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 2007;50:1743-51 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1661

SKU :

1661/10

product name :

SB 206553 hydrochloride

description :

Potent and selective 5-HT2B and 5-HT2C antagonist; orally active

target :

5-HT2C Receptor Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Desiccate at RT

observed molecular weight :

328.8

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 206553 hydrochloride is a potent and selective 5-HT2B/5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92). Displays 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pKi 6). Centrally active following oral administration in vivo .

product keywords :

Potent selective 5-HT2C/5-HT2B antagonists Serotonin 5-HT2B Receptors 5-HT2C SB206553 hydrochloride GlaxoSmithKline GSK 5-HT2C Receptors 5-HT2B Receptors 1661,

extended description :

Potent and selective 5-HT2B and 5-HT2C antagonist; orally active

chemical name text :

3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b ]dipyrrole-1(2H)-carboxamide hydrochloride

formula :

C17H16N4O.HCl

formula text :

C17H16N4O.HCl

cas num :

1197334-04-5

USD :

296

USD 2025 :

299 USD

product details :

Potent and selective 5-HT2B and 5-HT2C antagonist; orally active

more info or order :

Tocris Bioscience product webpage