This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Tocris Bioscience
product type :
chemical
product name :
O-2050
catalog :
1655/10
quantity :
10 mg
price :
332 USD
citations: 8
Reference
Pinheiro B, Lemos C, Neutzling Kaufmann F, Marques J, da Silva Santos C, Carvalho E, et al. Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull. 2016;124:222-30 pubmed publisher
Alpár A, Tortoriello G, Calvigioni D, Niphakis M, Milenkovic I, Bakker J, et al. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. Nat Commun. 2014;5:4421 pubmed publisher
Prather P, Francisdevaraj F, Dates C, Greer A, Bratton S, Ford B, et al. CB1 and CB2 receptors are novel molecular targets for Tamoxifen and 4OH-Tamoxifen. Biochem Biophys Res Commun. 2013;441:339-43 pubmed publisher
Maleńczyk K, Jazurek M, Keimpema E, Silvestri C, Janikiewicz J, Mackie K, et al. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. J Biol Chem. 2013;288:32685-99 pubmed publisher
Keimpema E, Alpar A, Howell F, Maleńczyk K, Hobbs C, Hurd Y, et al. Diacylglycerol lipase ? manipulation reveals developmental roles for intercellular endocannabinoid signaling. Sci Rep. 2013;3:2093 pubmed publisher
Chimalakonda K, Seely K, Bratton S, Brents L, Moran C, Endres G, et al. Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands. Drug Metab Dispos. 2012;40:2174-84 pubmed publisher
Brents L, Gallus Zawada A, Radominska Pandya A, Vasiljevik T, Prisinzano T, Fantegrossi W, et al. Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity. Biochem Pharmacol. 2012;83:952-61 pubmed publisher
Brents L, Reichard E, Zimmerman S, Moran J, Fantegrossi W, Prather P. Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity. PLoS ONE. 2011;6:e21917 pubmed publisher
product information
brand :
Tocris
master code :
1655
SKU :
1655/10
product name :
O-2050
description :
Putative CB1 antagonist; displays mixed activity at CB receptors
target :
Cannabinoid R1/CB1 Antagonists
category :
Small Molecules
unit size :
10 mg
purity :
97%
observed molecular weight :
417.56
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
O-2050 is an originally defined as a high affinity cannabinoid CB1 receptor silent antagonist. Acts as a partial agonist in inhibiting forksolin-induced cyclic AMP stimulation (EC50 = 40.4 nM). Decreases food intake and stimulates locomotor activity in rodents. Antagonizes effects of CP55,940 (Cat. No. 0949) in vitro .
catalog number base :
1655
extended description :
Putative CB1 antagonist; displays mixed activity at CB receptors
chemical name text :
(6aR,10aR)-1-Hydroxy-3-(1-Methanesulfonylamino-4-hexyn-6-yl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
formula :
C 23 H 31 NO 4 S
formula text :
C23H31NO4S
cas num :
1883545-42-3
USD 2021 :
314
USD 2022 :
332 USD
product details :
Putative CB1 antagonist; displays mixed activity at CB receptors
storage :
Store at -80°C
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK