product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Apamin
catalog :
1652/1
quantity :
1 mg
price :
384 USD
more info or order :
citations: 23
Reference
O Malley J, Seibt F, Chin J, Beierlein M. TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations. J Neurosci. 2020;40:4813-4823 pubmed publisher
Gutzmann J, Lin L, Hoffman D. Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus. Front Cell Neurosci. 2019;13:27 pubmed publisher
Fernández Fernández D, Cadaveira Mosquera A, Rueda Ruzafa L, Herrera Pérez S, Veale E, Reboreda A, et al. Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons. PLoS ONE. 2018;13:e0199282 pubmed publisher
Whitaker L, Warren B, Venniro M, Harte T, McPherson K, Beidel J, et al. Bidirectional Modulation of Intrinsic Excitability in Rat Prelimbic Cortex Neuronal Ensembles and Non-Ensembles after Operant Learning. J Neurosci. 2017;37:8845-8856 pubmed publisher
Sargin D, Oliver D, Lambe E. Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels. elife. 2016;5: pubmed publisher
Gamble George J, Baldi R, Halladay L, Kocharian A, Hartley N, Silva C, et al. Cyclooxygenase-2 inhibition reduces stress-induced affective pathology. elife. 2016;5: pubmed publisher
Henry F, Sugino K, Tozer A, Branco T, Sternson S. Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss. elife. 2015;4: pubmed publisher
Thompson J, Ji G, Neugebauer V. Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain. Mol Pain. 2015;11:51 pubmed publisher
Rau A, Chappell A, Butler T, Ariwodola O, Weiner J. Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress. J Neurosci. 2015;35:9730-40 pubmed publisher
Zachary S, Fuchs P. Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci. 2015;35:9701-6 pubmed publisher
Lee J, Ko E, Ahn K, Kim S, Rhee P. The role of K⁺ conductances in regulating membrane excitability in human gastric corpus smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2015;308:G625-33 pubmed publisher
Yu C, Ai T, Weiss J, Chen P. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. PLoS ONE. 2014;9:e96691 pubmed publisher
Turker I, Yu C, Chang P, Chen Z, Sohma Y, Lin S, et al. Amiodarone inhibits apamin-sensitive potassium currents. PLoS ONE. 2013;8:e70450 pubmed publisher
Alpert M, Alford S. Synaptic NMDA receptor-dependent Ca²? entry drives membrane potential and Ca²? oscillations in spinal ventral horn neurons. PLoS ONE. 2013;8:e63154 pubmed publisher
Hsueh C, Chang P, Hsieh Y, Reher T, Chen P, Lin S. Proarrhythmic effect of blocking the small conductance calcium activated potassium channel in isolated canine left atrium. Heart Rhythm. 2013;10:891-8 pubmed publisher
Few A, Nanou E, Watari H, Sullivan J, Scheuer T, Catterall W. Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release. Proc Natl Acad Sci U S A. 2012;109:E452-60 pubmed publisher
Meredith F, Li G, Rennie K. Postnatal expression of an apamin-sensitive k(ca) current in vestibular calyx terminals. J Membr Biol. 2011;244:81-91 pubmed publisher
Zemkova H, Stojilkovic S, Klein D. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology. 2011;152:3842-51 pubmed publisher
Chan S, Cipolla M. Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-?. FASEB J. 2011;25:3229-39 pubmed publisher
Geier P, Lagler M, Boehm S, Kubista H. Dynamic interplay of excitatory and inhibitory coupling modes of neuronal L-type calcium channels. Am J Physiol Cell Physiol. 2011;300:C937-49 pubmed publisher
Villalobos C, Andrade R. Visinin-like neuronal calcium sensor proteins regulate the slow calcium-activated afterhyperpolarizing current in the rat cerebral cortex. J Neurosci. 2010;30:14361-5 pubmed publisher
Lamy C, Goodchild S, Weatherall K, Jane D, Liégeois J, Seutin V, et al. Allosteric block of KCa2 channels by apamin. J Biol Chem. 2010;285:27067-77 pubmed publisher
Han P, Nakanishi S, Tran M, Whelan P. Dopaminergic modulation of spinal neuronal excitability. J Neurosci. 2007;27:13192-204 pubmed
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
1652
SKU :
1652/1
product name :
Apamin
description :
KCa2 (SK) channel blocker
target :
Ca2+-Activated Potassium Channel Blockers
unit size :
1 mg
category :
Peptides
purity :
95%
storage :
Store at -20°C
observed molecular weight :
2027.34
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
Apamin is a potent and highly selective inhibitor of small-conductance Ca2+-activated K+-channels (KCa2, SK) (IC50 values are 87.7 pM, 2.3 nM and 4.1 nM for KCa2.2, KCa2.3 and KCa2.1 channels, respectively). Reduces release and mRNA expression of inflammatory cytokines TNF and IL-6. In models of kidney and cardiovascular disease apamin ameliorates tissue injury and dysfunction. Brain penetrant, blocks medium after-hyperpolarization in vitro , reduces neuroinflammation, increases microglia node contacts and Purkinje cell instananeous firing frequency.
product keywords :
K+ channels blockers small conductance ca2+-activated ca2+-dependent Potassium KCa KCa2 SK venoms Ca2+-Activated Potassium Channels 1652,
extended description :
KCa2 (SK) channel blocker
formula :
C79H131N31O24S4
formula text :
C79H131N31O24S4
cas num :
24345-16-2
USD :
368
USD 2025 :
384 USD
product details :
KCa2 (SK) channel blocker
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK