8-CPT-2Me-cAMP, sodium salt | Tocris Bioscience 1645/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8-CPT-2Me-cAMP, sodium salt

catalog :

1645/1

quantity :

1 mg

price :

251 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Ng P, McIntosh K, Hargrave G, Ho K, Paul A, Plevin R. Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells. Cell Signal. 2018;51:59-71 pubmed publisher
Mohan S, Narumiya S, DorÃ© S. Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity. Neurotoxicology. 2015;46:53-9 pubmed publisher
Hutchison M, White P. Prostacyclin regulates bone growth via the Epac/Rap1 pathway. Endocrinology. 2015;156:499-510 pubmed publisher
Chuang J, Kjalarsdottir L, Sakata I, Walker A, Kuperman A, Osborne Lawrence S, et al. Role of calcium and EPAC in norepinephrine-induced ghrelin secretion. Endocrinology. 2014;155:98-107 pubmed publisher
Guichard A, Cruz Moreno B, Cruz Moreno B, Aguilar B, van Sorge N, Kuang J, et al. Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe. 2013;14:294-305 pubmed publisher
Garcia Murillas I, Sharpe R, Pearson A, Campbell J, Natrajan R, Ashworth A, et al. An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer. Oncogene. 2014;33:2478-86 pubmed publisher
Hu F, Ren J, Zhang J, Zhong W, Luo M. Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity. Proc Natl Acad Sci U S A. 2012;109:17681-6 pubmed publisher
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed publisher
Himer L, Csóka B, Selmeczy Z, Koscsó B, Pócza T, Pacher P, et al. Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death. FASEB J. 2010;24:2631-40 pubmed publisher
Soltoff S, Hedden L. Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells. J Biol Chem. 2010;285:13337-48 pubmed publisher
Scheibner K, Boodoo S, Collins S, Black K, Chan Li Y, Zarek P, et al. The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion. Am J Respir Cell Mol Biol. 2009;40:251-9 pubmed publisher
Jeong H, Li Z, Brown M, Sacks D. IQGAP1 binds Rap1 and modulates its activity. J Biol Chem. 2007;282:20752-62 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1645

SKU :

1645/1

product name :

8-CPT-2Me-cAMP, sodium salt

description :

Selective Epac activator

target :

EPAC Activators

unit size :

1 mg

category :

Small Molecules

purity :

99%

storage :

Store at -20°C

observed molecular weight :

507.82

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

8-CPT-2Me-cAMP, sodium salt is a selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 M), but not PKA (EC50 10 M). Stimulates Epac-mediated Ca2+-mediated Ca2+ release in pancreatic -cells in vitro . Cell permeable analog (Cat. No. 4853) also available.

product keywords :

Selective Epacs epac activators G Proteins Small Rap1 Rap2 GTPase EPAC 1645, EPAC

extended description :

Selective Epac activator

chemical name text :

8-(4-Chlorophenylthio)-2 -O-methyladenosine-3 ,5 -cyclic monophosphate sodium salt

formula :

C17H16ClN5O6PS.Na

formula text :

C17H16ClN5O6PS.Na

cas num :

634207-53-7

USD :

243

USD 2025 :

251 USD

product details :

Selective Epac activator

more info or order :

Tocris Bioscience product webpage