AY 9944 dihydrochloride | Tocris Bioscience 1639/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AY 9944 dihydrochloride

catalog :

1639/10

quantity :

10 mg

price :

231 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
van der Kant R, Langness V, Herrera C, Williams D, Fong L, Leestemaker Y, et al. Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell. 2019;24:363-375.e9 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1639

SKU :

1639/10

product name :

AY 9944 dihydrochloride

description :

Inhibitor of Hedgehog (Hh) signaling. Inhibits 7-dehydrocholesterol reductase

target :

Hedgehog Signaling Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

99%

storage :

Desiccate at RT

observed molecular weight :

464.3

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AY 9944 dihydrochloride is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits 7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo .

product keywords :

inhibitors inhibits hedgehog Hh signaling 7-dehydrocholesterol Delta7-dehydrocholesterol reductases Signalling DHCR Reductase Reductases AY9944 dihydrochloride Hedgehog Signaling Delta-Dehydrocholesterol Reductase 1639,

extended description :

Inhibitor of Hedgehog (Hh) signaling. Inhibits 7-dehydrocholesterol reductase

chemical name text :

trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride

formula :

C22H28Cl2N2.2HCl

formula text :

C22H28Cl2N2.2HCl

cas num :

366-93-8

USD :

228

USD 2025 :

231 USD

product details :

Inhibitor of Hedgehog (Hh) signaling. Inhibits 7-dehydrocholesterol reductase

more info or order :

Tocris Bioscience product webpage