IEM 1460 | Tocris Bioscience 1636/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

IEM 1460

catalog :

1636/10

quantity :

10 mg (also 50 mg)

price :

164 USD

more info or order :

Tocris Bioscience product webpage

citations: 17

Reference
Purkey A, Woolfrey K, Crosby K, Stich D, Chick W, Aoto J, et al. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell Rep. 2018;25:974-987.e4 pubmed publisher
Suyama S, Ralevski A, Liu Z, Dietrich M, Yada T, Simonds S, et al. Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons. elife. 2017;6: pubmed publisher
Kopach O, Krotov V, Goncharenko J, Voitenko N. Inhibition of Spinal Ca(2+)-Permeable AMPA Receptors with Dicationic Compounds Alleviates Persistent Inflammatory Pain without Adverse Effects. Front Cell Neurosci. 2016;10:50 pubmed publisher
Park P, Sanderson T, Amici M, Choi S, Bortolotto Z, Zhuo M, et al. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus. J Neurosci. 2016;36:622-31 pubmed publisher
Liu S, Zhang M, Cheng L, Shi J, Lu J, Zhuo M. Long-term upregulation of cortical glutamatergic AMPA receptors in a mouse model of chronic visceral pain. Mol Brain. 2015;8:76 pubmed publisher
Tang B, Luo D, Yang J, Xu X, Zhu B, Wang X, et al. Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex. Sci Rep. 2015;5:14099 pubmed publisher
Höft S, Griemsmann S, Seifert G, Steinhäuser C. Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus. Philos Trans R Soc Lond B Biol Sci. 2014;369:20130602 pubmed publisher
Chen S, Zhou H, Byun H, Pan H. Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms. J Pharmacol Exp Ther. 2013;347:765-72 pubmed publisher
Jin S, Arai J, Tian X, Kumar Singh R, Feig L. Acquisition of contextual discrimination involves the appearance of a RAS-GRF1/p38 mitogen-activated protein (MAP) kinase-mediated signaling pathway that promotes long term potentiation (LTP). J Biol Chem. 2013;288:21703-13 pubmed publisher
Caba ero D, Baker A, Zhou S, Hargett G, Irie T, Xia Y, et al. Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord. Neuropsychopharmacology. 2013;38:1472-84 pubmed publisher
Colgan L, Cavolo S, Commons K, Levitan E. Action potential-independent and pharmacologically unique vesicular serotonin release from dendrites. J Neurosci. 2012;32:15737-46 pubmed publisher
Fortin D, Srivastava T, Dwarakanath D, Pierre P, Nygaard S, Derkach V, et al. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors. J Neurosci. 2012;32:8127-37 pubmed publisher
Case D, Zhao X, Gillespie D. Functional refinement in the projection from ventral cochlear nucleus to lateral superior olive precedes hearing onset in rat. PLoS ONE. 2011;6:e20756 pubmed publisher
Kopach O, Kao S, Petralia R, Belan P, Tao Y, Voitenko N. Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn. Pain. 2011;152:912-23 pubmed publisher
Santos S, Luz L, Szucs P, Lima D, Derkach V, Safronov B. Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord. PLoS ONE. 2009;4:e8047 pubmed publisher
Hildebrand M, Isope P, Miyazaki T, Nakaya T, Garcia E, Feltz A, et al. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci. 2009;29:9668-82 pubmed publisher
Guire E, Oh M, Soderling T, Derkach V. Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase I. J Neurosci. 2008;28:6000-9 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1636

SKU :

1636/10

product name :

IEM 1460

description :

Open-channel blocker of AMPA currents; selective for non-GluA2-containing receptors

target :

AMPA Receptor Blockers

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at RT

observed molecular weight :

454.33

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

IEM 1460 is a voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca2+-permeable) receptors over GluA2-containing receptors (IC50 values are 2.6 and 1102 u M, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo .

product keywords :

Open-channel blockers AMPA currents selective non-GluR2-containing receptors NMDA blocks Glutamate Receptors iGluR Ionotropic N-Methyl-D-Aspartate IEM1460 neuron neurones medium spiny neurons fast spiking interneurons MSNs FSIs GluA2 AMPA Receptors NMDA Receptors 1636,

extended description :

Open-channel blocker of AMPA currents; selective for non-GluA2-containing receptors

chemical name text :

N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide

formula :

C19H37N2Br.HBr

formula text :

C19H37N2Br.HBr

cas num :

121034-89-7

USD :

157

USD 2025 :

164 USD

product details :

Open-channel blocker of AMPA currents; selective for non-GluA2-containing receptors

more info or order :

Tocris Bioscience product webpage