RP 67580 | Tocris Bioscience 1635 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RP 67580

catalog :

1635

quantity :

10 mg (also 50 mg)

price :

233 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Wang G, Wang X, Liu S, Qu M, Xia Y, Needleman B, et al. Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine. Am J Physiol Gastrointest Liver Physiol. 2014;307:G719-31 pubmed publisher
Russell F, Schuelert N, Veldhoen V, Hollenberg M, McDougall J. Activation of PAR(2) receptors sensitizes primary afferents and causes leukocyte rolling and adherence in the rat knee joint. Br J Pharmacol. 2012;167:1665-78 pubmed publisher
Zhong B, Wang D. Protease-activated receptor 2-mediated protection of myocardial ischemia-reperfusion injury: role of transient receptor potential vanilloid receptors. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1681-90 pubmed publisher
Wang Y, Novotny M, Quaiserová Mocko V, Swain G, Wang D. TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1517-23 pubmed publisher

product information

brand :

Tocris

master code :

1635

SKU :

1635/10

product name :

RP 67580

description :

Potent and selective NK1 antagonist

target :

NK1 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

438.57

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective tachykinin NK1 receptor antagonist (Ki values are 2.9 nM and 10 u M for rat NK1, and rat NK2 and NK3 receptors respectively). Displays higher affinity at rat and mouse than human receptors. Antinociceptive in vivo , possibly partly via inhibition of calcium channels.

catalog number base :

1635

product keywords :

Potent selective NK1 antagonists Tachykinin Receptors Neurokinin RP67580 NK1 Receptor 1635, Neurokinin NK1

extended description :

Potent and selective NK1 antagonist

chemical name text :

(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol

formula :

C 29 H 30 N 2 O 2

formula text :

C29H30N2O2

cas num :

135911-02-3

2020 USD :

224

2021 USD :

233 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage