RP 67580 | Tocris Bioscience 1635/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RP 67580

catalog :

1635/10

quantity :

10 mg (also 50 mg)

price :

292 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Jeong Y, Cheng X, Kim W. Substance P Administered after Myocardial Infarction Upregulates Microphthalmia-Associated Transcription Factor, GATA4, and the Expansion of c-Kit+ Cells. Stem Cells Int. 2020;2020:1835950 pubmed publisher
Wang G, Wang X, Liu S, Qu M, Xia Y, Needleman B, et al. Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine. Am J Physiol Gastrointest Liver Physiol. 2014;307:G719-31 pubmed publisher
Chai B, Guo W, Wei F, Dubner R, Ren K. Trigeminal-rostral ventromedial medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury. Mol Pain. 2012;8:78 pubmed publisher
Russell F, Schuelert N, Veldhoen V, Hollenberg M, McDougall J. Activation of PAR(2) receptors sensitizes primary afferents and causes leukocyte rolling and adherence in the rat knee joint. Br J Pharmacol. 2012;167:1665-78 pubmed publisher
Zhong B, Wang D. Protease-activated receptor 2-mediated protection of myocardial ischemia-reperfusion injury: role of transient receptor potential vanilloid receptors. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1681-90 pubmed publisher
Wang Y, Novotny M, Quaiserová Mocko V, Swain G, Wang D. TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1517-23 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1635

SKU :

1635/10

product name :

RP 67580

description :

Potent and selective NK1 antagonist

target :

NK1 Receptor Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

97%

storage :

Store at -20°C

observed molecular weight :

438.57

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

RP 67580 is a potent and selective tachykinin NK1 receptor antagonist (Ki values are 2.9 nM and 10 u M for rat NK1, and rat NK2 and NK3 receptors respectively). Displays higher affinity at rat and mouse than human receptors. Antinociceptive in vivo , possibly partly via inhibition of calcium channels.

product keywords :

Potent selective NK1 antagonists Tachykinin Receptors Neurokinin RP67580 NK1 Receptor 1635, Neurokinin NK1

extended description :

Potent and selective NK1 antagonist

chemical name text :

(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol

formula :

C29H30N2O2

formula text :

C29H30N2O2

cas num :

135911-02-3

USD :

289

USD 2025 :

292 USD

product details :

Potent and selective NK1 antagonist

more info or order :

Tocris Bioscience product webpage