Calphostin C | Tocris Bioscience 1626/100U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Calphostin C

catalog :

1626/100U

quantity :

100 ug

price :

246 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Kou Z, Mo J, Wu K, Qiu M, Huang Y, Tao F, et al. Vascular endothelial growth factor increases the function of calcium-impermeable AMPA receptor GluA2 subunit in astrocytes via activation of protein kinase C signaling pathway. Glia. 2019;67:1344-1358 pubmed publisher
Arnold C, Demirel E, Feldner A, Genove G, Zhang H, Sticht C, et al. Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5. FASEB J. 2017;: pubmed publisher
Merino B, Quesada I, HernÃ¡ndez Cascales J. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. PLoS ONE. 2015;10:e0132884 pubmed publisher
Cao S, Chao D, Zhou H, Balboni G, Xia Y. A novel mechanism for cytoprotection against hypoxic injury: Î´-opioid receptor-mediated increase in Nrf2 translocation. Br J Pharmacol. 2015;172:1869-81 pubmed publisher
Liang J, Chao D, Sandhu H, Yu Y, Zhang L, Balboni G, et al. ?-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes. Br J Pharmacol. 2014;171:5417-30 pubmed publisher
Most P, Lerchenmüller C, Rengo G, Mahlmann A, Ritterhoff J, Rohde D, et al. S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation. Circ Res. 2013;112:66-78 pubmed publisher
Kaul A, Maltese W. Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress. Neoplasia. 2009;11:823-34 pubmed

product information

brand :

Tocris

master code :

1626

SKU :

1626/100U

product name :

Calphostin C

description :

Potent, selective and photo-dependent PKC inhibitor

target :

Protein Kinase C Inhibitors

category :

Small Molecules

unit sizes :

100 ug

purity :

95%

observed molecular weight :

790.76

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Calphostin C is a potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Displays 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC50 ~ 40 - 60 nM). Also an antagonist of the Tcf/ -catenin complex.

extended description :

Potent, selective and photo-dependent PKC inhibitor

chemical name text :

(1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester

formula :

C 44 H 38 O 14

formula text :

C44H38O14

cas num :

121263-19-2

USD :

246 USD

product details :

Potent, selective and photo-dependent PKC inhibitor

alt names :

UCN 1028C, PKF 115584

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage