2-Methylthioadenosine diphosphate trisodium salt | Tocris Bioscience 1624/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

2-Methylthioadenosine diphosphate trisodium salt

catalog :

1624/10

quantity :

10 mg

price :

406 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Zhang W, Bonadiman A, Ciorraga M, Benitez M, Garrido J. P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development. Front Cell Neurosci. 2019;13:152 pubmed publisher
Hilt Z, Pariser D, Ture S, Mohan A, Quijada P, Asante A, et al. Platelet-derived β2M regulates monocyte inflammatory responses. JCI Insight. 2019;: pubmed publisher
Lu W, Gómez N, Lim J, Guha S, O Brien Jenkins A, Coffey E, et al. The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration. Front Pharmacol. 2018;9:242 pubmed publisher
Manne B, Münzer P, Badolia R, Walker Allgaier B, Campbell R, Middleton E, et al. PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway. J Thromb Haemost. 2018;16:1211-1225 pubmed publisher
Madry C, Kyrargyri V, Arancibia Carcamo I, Jolivet R, Kohsaka S, Bryan R, et al. Microglial Ramification, Surveillance, and Interleukin-1? Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron. 2018;97:299-312.e6 pubmed publisher
Modjeski K, Ture S, Field D, Cameron S, Morrell C. Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation. PLoS ONE. 2016;11:e0160638 pubmed publisher
Zhang J, Zhang K, Gao Z, Paoletta S, Zhang D, Han G, et al. Agonist-bound structure of the human P2Y12 receptor. Nature. 2014;509:119-22 pubmed publisher
Voss U, Turesson M, Robaye B, Boeynaems J, Olde B, Erlinge D, et al. The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss. Purinergic Signal. 2014;10:455-64 pubmed publisher
Ilatovskaya D, Palygin O, Levchenko V, Staruschenko A. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol. 2013;305:C1050-9 pubmed publisher
Yamanaka K, Dorjsuren D, Eoff R, Egli M, Maloney D, Jadhav A, et al. A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. PLoS ONE. 2012;7:e45032 pubmed publisher
Wang F, Smith N, Xu Q, Fujita T, Baba A, Matsuda T, et al. Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+. Sci Signal. 2012;5:ra26 pubmed publisher
Ohtani M, Suzuki J, Jacobson K, Oka T. Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and insulin secretion in mouse pancreatic islets. Purinergic Signal. 2008;4:365-75 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1624

SKU :

1624/10

product name :

2-Methylthioadenosine diphosphate trisodium salt

description :

Potent agonist at P2Y1, P2Y12 and P2Y13

target :

P2Y Receptor Agonists

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

539.24

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

2-Methylthioadenosine diphosphate trisodium salt is a potent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro .

product keywords :

Potent agonists P2Y1 P2Y12 P2Y13 Receptors Purinergic purinoceptors p2yt 2-methylthio-ADP 2MeSADP ME2SADP 2-(Methylthio)adenosine 5'-diphosphate 2-Methylthio-ADP MeSADP Purinergic P2Y Receptors 1624,

extended description :

Potent agonist at P2Y1, P2Y12 and P2Y13

chemical name text :

2-(Methylthio)adenosine-5 -(trihydrogen diphosphate) trisodium salt

formula :

C11H14N5Na3O10P2S

formula text :

C11H14N5Na3O10P2S

cas num :

475193-31-8

USD :

389

USD 2025 :

406 USD

product details :

Potent agonist at P2Y1, P2Y12 and P2Y13

alt names :

2-(Methylthio)adenosine 5 -diphosphate,2-Methylthio-ADP,MeSADP

more info or order :

Tocris Bioscience product webpage