Cyclopamine | Tocris Bioscience 1623 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Cyclopamine

catalog :

1623

quantity :

1 mg

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Atzmon A, Herrero M, Sharet Eshed R, Gilad Y, Senderowitz H, Elroy Stein O. Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy. Front Mol Neurosci. 2018;11:336 pubmed publisher
Yan C, Yang Q, Huo X, Li H, Zhou L, Gong Z. Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish. Sci Rep. 2017;7:45796 pubmed publisher
Rodrigues A, Yakushiji Kaminatsui N, Atsuta Y, Andrey G, Schorderet P, Duboule D, et al. Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells. Proc Natl Acad Sci U S A. 2017;114:3139-3144 pubmed publisher
Yuan X, Cao J, He X, Serra R, Qu J, Cao X, et al. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation. Nat Commun. 2016;7:11024 pubmed publisher
Kumar N, Richter J, Cutts J, Bush K, Trujillo C, Nigam S, et al. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. elife. 2015;4: pubmed publisher
Zou J, Hong Y, Tong Y, Wei J, Qin Y, Shao S, et al. Sonic hedgehog produced by bone marrow-derived mesenchymal stromal cells supports cell survival in myelodysplastic syndrome. Stem Cells Int. 2015;2015:957502 pubmed publisher
Moisan A, Lee Y, Zhang J, Hudak C, Meyer C, Prummer M, et al. White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015;17:57-67 pubmed publisher
Atwood S, Li M, Lee A, Tang J, Oro A. GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas. Nature. 2013;494:484-8 pubmed publisher

product information

brand :

Tocris

master code :

1623

SKU :

1623/1

product name :

Cyclopamine

description :

Inhibitor of Hedgehog (Hh) signaling

target :

Hedgehog Signaling Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

97%

observed molecular weight :

411.63

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anticancer and teratogenic in vivo . Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

catalog number base :

1623

product keywords :

inhibitors inhibits hedgehog Hh signaling Signalling Hedgehog stem cells Smo smoothened antagonist Hedgehog Signaling Stem Cell Signaling Smoothened Receptors Cancer Stem Cells ESCs and iPSC 1623,

extended description :

Inhibitor of Hedgehog (Hh) signaling

chemical name text :

(2 R,3S,3 R,3 aS,6 S,6aS,6bS,7 aR,11aS,11bR)-1,2,3,3 a,4,4 ,5 ,6,6 ,6a,6b,7,7 ,7 a,8,11,11a,11b-Octadecahydro-3 ,6 ,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2 (3 H)-furo[3,2-b]pyridin]-3-ol

formula :

C 27 H 41 NO 2

formula text :

C27H41NO2

cas num :

4449-51-8

2020 USD :

205

2021 USD :

216 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage