Cyclopamine | Tocris Bioscience 1623/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Cyclopamine

catalog :

1623/1

quantity :

1 mg

price :

280 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Atzmon A, Herrero M, Sharet Eshed R, Gilad Y, Senderowitz H, Elroy Stein O. Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy. Front Mol Neurosci. 2018;11:336 pubmed publisher
Múnera J, Sundaram N, Rankin S, Hill D, Watson C, Mahe M, et al. Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling. Cell Stem Cell. 2017;21:51-64.e6 pubmed publisher
Yan C, Yang Q, Huo X, Li H, Zhou L, Gong Z. Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish. Sci Rep. 2017;7:45796 pubmed publisher
Rodrigues A, Yakushiji Kaminatsui N, Atsuta Y, Andrey G, Schorderet P, Duboule D, et al. Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells. Proc Natl Acad Sci U S A. 2017;114:3139-3144 pubmed publisher
Yuan X, Cao J, He X, Serra R, Qu J, Cao X, et al. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation. Nat Commun. 2016;7:11024 pubmed publisher
Kumar N, Richter J, Cutts J, Bush K, Trujillo C, Nigam S, et al. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. elife. 2015;4: pubmed publisher
Zou J, Hong Y, Tong Y, Wei J, Qin Y, Shao S, et al. Sonic hedgehog produced by bone marrow-derived mesenchymal stromal cells supports cell survival in myelodysplastic syndrome. Stem Cells Int. 2015;2015:957502 pubmed publisher
Handorf A, Chamberlain C, Li W. Endogenously produced Indian Hedgehog regulates TGFÎ²-driven chondrogenesis of human bone marrow stromal/stem cells. Stem Cells Dev. 2015;24:995-1007 pubmed publisher
Moisan A, Lee Y, Zhang J, Hudak C, Meyer C, Prummer M, et al. White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015;17:57-67 pubmed publisher
Deschaseaux F, Gaillard J, Langonne A, Chauveau C, Naji A, Bouacida A, et al. Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue. FASEB J. 2013;27:2977-87 pubmed publisher
Atwood S, Li M, Lee A, Tang J, Oro A. GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas. Nature. 2013;494:484-8 pubmed publisher
Brafman D, Phung C, Kumar N, Willert K. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 2013;20:369-81 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1623

SKU :

1623/1

product name :

Cyclopamine

description :

Inhibitor of Hedgehog (Hh) signaling

target :

Hedgehog Signaling Inhibitors

unit size :

1 mg

category :

Small Molecules

purity :

97%

storage :

Desiccate at -20°C

observed molecular weight :

411.63

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cyclopamine is an inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anticancer and teratogenic in vivo . Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

product keywords :

inhibitors inhibits hedgehog Hh signaling Signalling Hedgehog stem cells Smo smoothened antagonist Hedgehog Signaling Stem Cell Signaling Smoothened Receptors Cancer Stem Cells ESCs and iPSC 1623,

extended description :

Inhibitor of Hedgehog (Hh) signaling

chemical name text :

(2 R,3S,3 R,3 aS,6 S,6aS,6bS,7 aR,11aS,11bR)-1,2,3,3 a,4,4 ,5 ,6,6 ,6a,6b,7,7 ,7 a,8,11,11a,11b-Octadecahydro-3 ,6 ,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2 (3 H)-furo[3,2-b]pyridin]-3-ol

formula :

C27H41NO2

formula text :

C27H41NO2

cas num :

4449-51-8

USD :

268

USD 2025 :

280 USD

product details :

Inhibitor of Hedgehog (Hh) signaling

more info or order :

Tocris Bioscience product webpage