product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
SB 415286
catalog :
1617/10
quantity :
10 mg (also 50 mg)
price :
264 USD
more info or order :
citations: 30
Reference |
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Noh K, Cho J, Chun S, Jang J, Cha G, Jung I, et al. Resveratrol regulates naïve CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression. BMB Rep. 2015;48:283-8 pubmed
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Noh K, Son K, Jung I, Kang H, Hwang S, Lee W, et al. Protein kinase C ? (PKC?)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia. J Biol Chem. 2012;287:14226-33 pubmed publisher
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Garvalov B, FLYNN K, Neukirchen D, Meyn L, Teusch N, Wu X, et al. Cdc42 regulates cofilin during the establishment of neuronal polarity. J Neurosci. 2007;27:13117-29 pubmed
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Ishola T, Kang J, Qiao J, Evers B, Chung D. Phosphatidylinositol 3-kinase regulation of gastrin-releasing peptide-induced cell cycle progression in neuroblastoma cells. Biochim Biophys Acta. 2007;1770:927-32 pubmed
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Gärtner A, Huang X, Hall A. Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3beta) independently of Akt/PKB serine phosphorylation. J Cell Sci. 2006;119:3927-34 pubmed
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Streets A, Moon D, Kane M, Obara T, Ong A. Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro. Hum Mol Genet. 2006;15:1465-73 pubmed
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Gross E, Hsu A, Gross G. Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. Circ Res. 2004;94:960-6 pubmed
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product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
1617
SKU :
1617/10
product name :
SB 415286
description :
Potent, selective GSK-3 inhibitor
target :
GSK-3 Inhibitors
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Store at RT
observed molecular weight :
359.73
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SB 415286 is a potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3 ); competes with ATP. Has minimal activity against 24 other protein kinases (IC50 10 u M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.
product keywords :
Potent selective GSK-3 inhibitors inhibits Glycogen Synthase Kinases 3 Carbohydrate Metabolism SB415286 GlaxoSmithKline GSK Glycogen Synthase Kinase 3 Glycogen Synthase Kinase 1617,
extended description :
Potent, selective GSK-3 inhibitor
chemical name text :
3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
formula :
C16H10ClN3O5
formula text :
C16H10ClN3O5
cas num :
264218-23-7
USD :
261
USD 2025 :
264 USD
product details :
Potent, selective GSK-3 inhibitor
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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