product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
SB 415286
catalog :
1617/10
quantity :
10 mg (also 50 mg)
price :
264 USD
more info or order :
citations: 30
Reference
Napolitano G, Esposito A, Choi H, Matarese M, Benedetti V, Di Malta C, et al. mTOR-dependent phosphorylation controls TFEB nuclear export. Nat Commun. 2018;9:3312 pubmed publisher
Liddell J, Lehtonen S, Duncan C, Keksa Goldsteine V, Levonen A, Goldsteins G, et al. Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation. 2016;13:49 pubmed publisher
Stretton C, Hoffmann T, Munson M, Prescott A, Taylor P, Ganley I, et al. GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling. Biochem J. 2015;470:207-21 pubmed publisher
Vossel K, Xu J, Fomenko V, Miyamoto T, Suberbielle E, Knox J, et al. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. J Cell Biol. 2015;209:419-33 pubmed publisher
Wang X, Wei L, Cramer J, Leibowitz B, Judge C, Epperly M, et al. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015;5:8566 pubmed publisher
Noh K, Son K, Jung I, Kang T, Choi C, Park Y. Glycogen Synthase Kinase-3β (GSK-3β) Inhibition Enhances Dendritic Cell-based Cancer Vaccine Potency via Suppression of Interferon-γ-induced Indoleamine 2,3-Dioxygenase Expression. J Biol Chem. 2015;290:12394-402 pubmed publisher
Cuesto G, Jordán Álvarez S, Enriquez Barreto L, Ferrús A, Morales M, Acebes A. GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. PLoS ONE. 2015;10:e0118475 pubmed publisher
Noh K, Cho J, Chun S, Jang J, Cha G, Jung I, et al. Resveratrol regulates naïve CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression. BMB Rep. 2015;48:283-8 pubmed
Lee C, Lento W, Castle K, Chao N, Kirsch D. Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice. Radiat Res. 2014;181:445-51 pubmed publisher
Acevedo K, Opazo C, Norrish D, Challis L, Li Q, White A, et al. Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells. J Biol Chem. 2014;289:11007-19 pubmed publisher
Westhoff M, Faham N, Marx D, Nonnenmacher L, Jennewein C, Enzenmüller S, et al. Sequential dosing in chemosensitization: targeting the PI3K/Akt/mTOR pathway in neuroblastoma. PLoS ONE. 2013;8:e83128 pubmed publisher
Chen C, Lin C, Wan S, Wei L, Chen M, Yeh T, et al. Anti-dengue virus nonstructural protein 1 antibodies cause NO-mediated endothelial cell apoptosis via ceramide-regulated glycogen synthase kinase-3β and NF-κB activation. J Immunol. 2013;191:1744-52 pubmed publisher
Ray D, Shukla S, Allam U, Helman A, Ramanand S, Tran L, et al. Tristetraprolin mediates radiation-induced TNF-? production in lung macrophages. PLoS ONE. 2013;8:e57290 pubmed publisher
Sharma P, Kolawole A, Core S, Kajon A, Excoffon K. Sidestream smoke exposure increases the susceptibility of airway epithelia to adenoviral infection. PLoS ONE. 2012;7:e49930 pubmed publisher
Noh K, Son K, Jung I, Kang H, Hwang S, Lee W, et al. Protein kinase C ? (PKC?)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia. J Biol Chem. 2012;287:14226-33 pubmed publisher
Gupta K, Gulen F, Sun L, Aguilera R, Chakrabarti A, Kiselar J, et al. GSK3 is a regulator of RAR-mediated differentiation. Leukemia. 2012;26:1277-85 pubmed publisher
Thotala D, Hallahan D, Yazlovitskaya E. Glycogen synthase kinase 3? inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway. Cell Death Differ. 2012;19:387-96 pubmed publisher
Yang E, Nowsheen S, Wang T, Thotala D, Xia F. Glycogen synthase kinase 3beta inhibition enhances repair of DNA double-strand breaks in irradiated hippocampal neurons. Neuro Oncol. 2011;13:459-70 pubmed publisher
Dickey A, Schleicher S, Leahy K, Hu R, Hallahan D, Thotala D. GSK-3β inhibition promotes cell death, apoptosis, and in vivo tumor growth delay in neuroblastoma Neuro-2A cell line. J Neurooncol. 2011;104:145-53 pubmed publisher
Severson E, Kwon M, Hilgarth R, Parkos C, Nusrat A. Glycogen Synthase Kinase 3 (GSK-3) influences epithelial barrier function by regulating occludin, claudin-1 and E-cadherin expression. Biochem Biophys Res Commun. 2010;397:592-7 pubmed publisher
Tsai L, Leng Y, Wang Z, Leeds P, Chuang D. The mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanisms. Neuropsychopharmacology. 2010;35:2225-37 pubmed publisher
Nyati S, Ranga R, Ross B, Rehemtulla A, Bhojani M. Molecular imaging of glycogen synthase kinase-3beta and casein kinase-1alpha kinases. Anal Biochem. 2010;405:246-54 pubmed publisher
Thotala D, Geng L, Dickey A, Hallahan D, Yazlovitskaya E. A new class of molecular targeted radioprotectors: GSK-3beta inhibitors. Int J Radiat Oncol Biol Phys. 2010;76:557-65 pubmed publisher
Watanabe T, Noritake J, Kakeno M, Matsui T, Harada T, Wang S, et al. Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules. J Cell Sci. 2009;122:2969-79 pubmed publisher
Witte H, Neukirchen D, Bradke F. Microtubule stabilization specifies initial neuronal polarization. J Cell Biol. 2008;180:619-32 pubmed publisher
Garvalov B, FLYNN K, Neukirchen D, Meyn L, Teusch N, Wu X, et al. Cdc42 regulates cofilin during the establishment of neuronal polarity. J Neurosci. 2007;27:13117-29 pubmed
Ishola T, Kang J, Qiao J, Evers B, Chung D. Phosphatidylinositol 3-kinase regulation of gastrin-releasing peptide-induced cell cycle progression in neuroblastoma cells. Biochim Biophys Acta. 2007;1770:927-32 pubmed
Gärtner A, Huang X, Hall A. Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3beta) independently of Akt/PKB serine phosphorylation. J Cell Sci. 2006;119:3927-34 pubmed
Streets A, Moon D, Kane M, Obara T, Ong A. Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro. Hum Mol Genet. 2006;15:1465-73 pubmed
Gross E, Hsu A, Gross G. Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. Circ Res. 2004;94:960-6 pubmed
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
1617
SKU :
1617/10
product name :
SB 415286
description :
Potent, selective GSK-3 inhibitor
target :
GSK-3 Inhibitors
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Store at RT
observed molecular weight :
359.73
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SB 415286 is a potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3 ); competes with ATP. Has minimal activity against 24 other protein kinases (IC50 10 u M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.
product keywords :
Potent selective GSK-3 inhibitors inhibits Glycogen Synthase Kinases 3 Carbohydrate Metabolism SB415286 GlaxoSmithKline GSK Glycogen Synthase Kinase 3 Glycogen Synthase Kinase 1617,
extended description :
Potent, selective GSK-3 inhibitor
chemical name text :
3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
formula :
C16H10ClN3O5
formula text :
C16H10ClN3O5
cas num :
264218-23-7
USD :
261
USD 2025 :
264 USD
product details :
Potent, selective GSK-3 inhibitor
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK