SB 366791 | Tocris Bioscience 1615 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 366791

catalog :

1615

quantity :

10 mg (also 50 mg)

price :

173 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Li Y, Adamek P, Zhang H, Tatsui C, Rhines L, Mrozkova P, et al. The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4. J Neurosci. 2015;35:13487-500 pubmed publisher
Wang G, Wang X, Liu S, Qu M, Xia Y, Needleman B, et al. Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine. Am J Physiol Gastrointest Liver Physiol. 2014;307:G719-31 pubmed publisher
Nguyen T, Kwon S, Hong S, Ma S, Jung Y, Hwang J, et al. Transient receptor potential vanilloid type 1 channel may modulate opioid reward. Neuropsychopharmacology. 2014;39:2414-22 pubmed publisher
Alvarez Berdugo D, Jiménez M, Clave P, Rofes L. Pharmacodynamics of TRPV1 agonists in a bioassay using human PC-3 cells. ScientificWorldJournal. 2014;2014:184526 pubmed publisher
Graham D, Huang L, Robinson K, Messerli M. Epidermal keratinocyte polarity and motility require Ca²? influx through TRPV1. J Cell Sci. 2013;126:4602-13 pubmed publisher
Shabir S, Cross W, Kirkwood L, Pearson J, Appleby P, Walker D, et al. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Am J Physiol Renal Physiol. 2013;305:F396-406 pubmed publisher
Ambrosino P, Soldovieri M, Russo C, Taglialatela M. Activation and desensitization of TRPV1 channels in sensory neurons by the PPAR? agonist palmitoylethanolamide. Br J Pharmacol. 2013;168:1430-44 pubmed publisher
Casarotto P, Terzian A, Aguiar D, Zangrossi H, Guimarães F, Wotjak C, et al. Opposing roles for cannabinoid receptor type-1 (CB?) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats. Neuropsychopharmacology. 2012;37:478-86 pubmed publisher
Hazari M, Haykal Coates N, Winsett D, Krantz Q, King C, Costa D, et al. TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmias in hypertensive rats exposed to diesel exhaust. Environ Health Perspect. 2011;119:951-7 pubmed publisher
Yuan S, Burrell B. Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor. J Neurophysiol. 2010;104:2766-77 pubmed publisher
Schuelert N, Zhang C, Mogg A, Broad L, Hepburn D, Nisenbaum E, et al. Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain. Osteoarthritis Cartilage. 2010;18:1536-43 pubmed publisher
Westlund K, Kochukov M, Lu Y, McNearney T. Impact of central and peripheral TRPV1 and ROS levels on proinflammatory mediators and nociceptive behavior. Mol Pain. 2010;6:46 pubmed publisher
Gavva N, Tamir R, Qu Y, Klionsky L, Zhang T, Immke D, et al. AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther. 2005;313:474-84 pubmed
Price T, Patwardhan A, Akopian A, Hargreaves K, Flores C. Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. Br J Pharmacol. 2004;142:257-66 pubmed

product information

brand :

Tocris

master code :

1615

SKU :

1615/10

product name :

SB 366791

description :

Potent and selective TRPV1 competitive antagonist

target :

TRPV Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

287.75

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, selective and competitive vanilloid TRPV1 receptor antagonist (pA2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB1 and CB2 receptors, voltage-gated Ca2+ channels and the hyperpolarization-activated current (Ih).

catalog number base :

1615

product keywords :

Potent selective competitive TRPV1 VR1 antagonists Vanillioids Receptors TRPV Channels Transient Receptor Potential SB366791 GlaxoSmithKline GSK TRPV 1615,

extended description :

Potent and selective TRPV1 competitive antagonist

chemical name text :

4 -Chloro-3-methoxycinnamanilide

formula :

C 16 H 14 ClNO 2

formula text :

C16H14ClNO2

cas num :

472981-92-3

2020 USD :

166

2021 USD :

173 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage